FBXO22
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Official Full Name
F-box protein 22 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. -
Synonyms
FBXO22;F-box protein 22;F box only protein 22;F-box only protein 22;FBX22;FIST domain containing 1;FISTC1;F-box protein FBX22p44;FLJ13986;MGC31799
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXO22-12790H | Recombinant Human FBXO22, GST-tagged | E.coli | Human | GST | 104-403a.a. | |
| FBXO22-1658R | Recombinant Rhesus monkey FBXO22 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| FBXO22-2259C | Recombinant Chicken FBXO22 | Mammalian Cell | Chicken | His |
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| FBXO22-3236Z | Recombinant Zebrafish FBXO22 | Mammalian Cell | Zebrafish | His |
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| FBXO22-3921H | Recombinant Human FBXO22 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXO22-480H | Recombinant Human FBXO22 Protein, His-tagged | E.coli | Human | His |
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| FBXO22-6304HCL | Recombinant Human FBXO22 293 Cell Lysate | HEK293 | Human | Non |
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| FBXO22-1482R | Recombinant Rhesus Macaque FBXO22 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| FBXO22-1482R-B | Recombinant Rhesus Macaque FBXO22 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| FBXO22-5026HF | Recombinant Full Length Human FBXO22 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 299 amino acids |
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Involved Pathway
FBXO22 involved in several pathways and played different roles in them. We selected most pathways FBXO22 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
FBXO22 has several biochemical functions, for example, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO22 itself. We selected most functions FBXO22 had, and list some proteins which have the same functions with FBXO22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | RNF139,AMFR,RNF20,UBE3A,RNF130,TRIM36,TRIM71,ITCHA,UBR4,SIAH1 |
Interacting Protein
FBXO22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO22 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO22.
COPS6;COPS5;NCOR2;midostaurin;SKP1
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