FBXL7
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Official Full Name
F-box and leucine-rich repeat protein 7 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. -
Synonyms
FBXL7;F-box and leucine-rich repeat protein 7;F-box/LRR-repeat protein 7;FBL6;FBL7;KIAA0840;F-box protein Fbl7;F-box protein FBL6/FBL7
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL7-1656R | Recombinant Rhesus monkey FBXL7 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| FBXL7-3910H | Recombinant Human FBXL7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXL7-5727M | Recombinant Mouse FBXL7 Protein | Mammalian Cell | Mouse | His |
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| FBXL7-273HCL | Recombinant Human FBXL7 lysate | HEK293 | Human | Non |
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| FBXL7-1480R | Recombinant Rhesus Macaque FBXL7 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| FBXL7-1480R-B | Recombinant Rhesus Macaque FBXL7 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| FBXL7-3151M | Recombinant Mouse FBXL7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXL7-3151M-B | Recombinant Mouse FBXL7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXL7-5005HF | Recombinant Full Length Human FBXL7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 491 amino acids |
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Involved Pathway
FBXL7 involved in several pathways and played different roles in them. We selected most pathways FBXL7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
FBXL7 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL7 itself. We selected most functions FBXL7 had, and list some proteins which have the same functions with FBXL7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | MALT1,RNF187,TRIM68,UBE2D3,TRAF4A,RNF139,FBXL14B,CDC23,RNF10,RNF38 |
| contributes_to ubiquitin protein ligase activity | MED12,FBXL3,FBXL18,CUL1,FBXL5,CUL2,FBXL3A,MED11,CUL5A,FBXL4 |
Interacting Protein
FBXL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL7.
b4dyc6_human;SKP1;NUDCD2;NUDC;ggt
Resources
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References
- Liu, Y; Lear, T; et al. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. CELL DEATH & DISEASE 6:-(2015).
- Rodrigues-Campos, M; Thompson, BJ; et al. The ubiquitin ligase FbxL7 regulates the Dachsous-Fat-Dachs system in Drosophila. DEVELOPMENT 141:4098-4103(2014).
