FBXL3
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Official Full Name
F-box and leucine-rich repeat protein 3 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. -
Synonyms
FBXL3;F-box and leucine-rich repeat protein 3;F box and leucine rich repeat protein 3A , FBXL3A;F-box/LRR-repeat protein 3;FBL3;FBL3A;F box and leucine rich repeat protein 3;F box and leucine rich repeat protein 3A;F box protein Fbl3a;FBXL3A;OTTHUMP00000018519;OTTHUMP00000018520;F-box protein Fbl3a;F-box/LRR-repeat protein 3A;F-box and leucine-rich repeat protein 3A
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL3-1654R | Recombinant Rhesus monkey FBXL3 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| FBXL3-32H | Recombinant Human FBXL3 protein, GST-tagged | Wheat Germ | Human | GST | 1-428 a.a. |
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| FBXL3-1478R | Recombinant Rhesus Macaque FBXL3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| FBXL3-1478R-B | Recombinant Rhesus Macaque FBXL3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Fbxl3-1630M | Recombinant Mouse Fbxl3 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Tyr292 |
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| FBXL3-580HF | Recombinant Full Length Human FBXL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 428 amino acids |
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Involved Pathway
FBXL3 involved in several pathways and played different roles in them. We selected most pathways FBXL3 participated on our site, such as Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | PER1,RORC,PRKAB2,PER2,RBX1,PRKAA2,PRKAG1,FBXW11,CRY2,CLOCK |
Protein Function
FBXL3 has several biochemical functions, for example, protein binding,contributes_to ubiquitin protein ligase activity,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL3 itself. We selected most functions FBXL3 had, and list some proteins which have the same functions with FBXL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | TSPAN17,FBXO40.1,UBE2A,BIRC3,RNF220,HECW1B,DZIP3,UBE2D3,FBXL5,UBA1 |
| protein binding | POGK,GSDMA2,FOXN3,ZNF165,RFC4,ARF4,SULT4A1,FAM19A1,LOX,USP36 |
| contributes_to ubiquitin-protein transferase activity | KLHL24,FBXW8,DDB2,DBN1,KLHDC5,KEAP1B,KLHL29,KLHL32,KLHL10,KBTBD5 |
| contributes_to ubiquitin protein ligase activity | CUL1A,MED12,C10orf46,FBXL15,CUL3,FBXL12,FBXL3B,FBXL17,SKP2,ANAPC2 |
Interacting Protein
FBXL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL3.
SKP1;HSP90AB1;Cry1;mviM1
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