FBXL14
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Official Full Name
F-box and leucine-rich repeat protein 14 -
Overview
Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif.;SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as;protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination;targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)). -
Synonyms
FBXL14;F-box and leucine-rich repeat protein 14;F-box/LRR-repeat protein 14;Fbl14;MGC40195
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL14-12772H | Recombinant Human FBXL14, His-tagged | E.coli | Human | His | 1-418a.a. | |
| FBXL14-1652R | Recombinant Rhesus monkey FBXL14 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| FBXL14-3890H | Recombinant Human FBXL14 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXL14-5713M | Recombinant Mouse FBXL14 Protein | Mammalian Cell | Mouse | His |
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| FBXL14-271HCL | Recombinant Human FBXL14 lysate | HEK293 | Human | Non |
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| FBXL14-1476R | Recombinant Rhesus Macaque FBXL14 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| FBXL14-1476R-B | Recombinant Rhesus Macaque FBXL14 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| FBXL14-3140M | Recombinant Mouse FBXL14 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXL14-3140M-B | Recombinant Mouse FBXL14 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXL14-4945HF | Recombinant Full Length Human FBXL14 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 418 amino acids |
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Involved Pathway
FBXL14 involved in several pathways and played different roles in them. We selected most pathways FBXL14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FBXL14 has several biochemical functions, for example, protein binding,contributes_to ubiquitin protein ligase activity,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL14 itself. We selected most functions FBXL14 had, and list some proteins which have the same functions with FBXL14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CNOT4,GTF3C4,PLEKHH2,TMEM64,TRIM74,HNF1A,IL23R,RYR2,GTPBP2,GUCY1A3 |
| contributes_to ubiquitin protein ligase activity | FBXL3A,MED11,CUL5A,CUL3,FBXL5,FBXL14B,FBXL3,MED12,CUL1,FBXL14A |
| ubiquitin-protein transferase activity | UBE2A,BIRC3,UBE2G2,FBXL5,PDZRN3,ZYG11,MUL1A,LRSAM1,TRIM56,TRIM5 |
Interacting Protein
FBXL14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL14 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL14.
b4dyc6_human;SNAI1;HSP90AB1;FKBP5;HSP90AB1;Hacd3;AARSD1
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References
- Silva, IMW; Rosenfeld, J; et al. A 1.5 Mb terminal deletion of 12p associated with autism spectrum disorder. GENE 542:83-86(2014).
- Vinas-Castells, R; Frias, A; et al. Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. NUCLEIC ACIDS RESEARCH 42:1079-1094(2014).
