FARSA
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Official Full Name
phenylalanyl-tRNA synthetase, alpha subunit -
Overview
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a;product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA;synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and;differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of;regulated expression. -
Synonyms
FARSA;phenylalanyl-tRNA synthetase, alpha subunit;FARSL, FARSLA, phenylalanine tRNA synthetase like , phenylalanyl tRNA synthetase like, alpha subunit;phenylalanyl-tRNA synthetase alpha chain;CML33;phenylalanine tRNA ligase 1;alpha;cytoplasmic;CML 33;FARS;FARSL;FRSA;PheHA;Phenylalanine tRNA ligase 1 alpha cytoplasmic;Phenylalanine tRNA ligase alpha chain;Phenylalanine tRNA synthetase alpha subunit;Phenylalanine tRNA synthetase like alpha subunit;Phenylalanyl tRNA synthetase alpha chain;Phenylalanyl tRNA synthetase alpha subunit;Phenylalanyl tRNA synthetase like alpha subunit;PheRS;phenylalanine--tRNA ligase alpha chain;phenylalanine-tRNA synthetase alpha-subunit;phenylalanine tRNA ligase 1, alpha, cytoplasmic;phenylalanyl-tRNA synthetase-like, alpha subunit;phenylalanine-tRNA synthetas;FARSLA
Recombinant Proteins
- Rhesus macaque
- Human
- Zebrafish
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
FARSA involved in several pathways and played different roles in them. We selected most pathways FARSA participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARSA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | DARS,DARS2,LARS,EARS2,VARS,CARS,GATB,WARS2,RARS2,IARS2 |
Protein Function
FARSA has several biochemical functions, for example, ATP binding,phenylalanine-tRNA ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FARSA itself. We selected most functions FARSA had, and list some proteins which have the same functions with FARSA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | XRN1,RBM10,CCDC9,PA2G4,PPIG,MADD,C9orf114,FAM133B,DIAPH1,SNRNP70 |
| tRNA binding | CTU2,XPOT,TERT,TRMU,SSB,TYW5,PTCD1,EEF1A1,YARS,CARS |
| phenylalanine-tRNA ligase activity | FARS2,FARSB,FDXACB1 |
| protein binding | ATG101,SIP1,ZNF649,SERPINE1,OTUD7B,CYFIP1,ITSN1,CD276,SIX4,SATB1 |
| ATP binding | SLK,SYN3,RIPK1L,DGKA,SWAP70,PAK2A,DDX59,PDK2,PIP4K2A,UBE2I |
Interacting Protein
FARSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARSA here. Most of them are supplied by our site. Hope this information will be useful for your research of FARSA.
ABI3;ECSIT;a8k1f4_human;USP11;PSMD2;USP32;HNRNPR;A2M;TDGF1;GORAB;XRCC3;EIF2AK2;LRRK2;Unc93b1
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References
- Miyazaki, K; et al. Molecular engineering of a PheS counterselection marker for improved operating efficiency in Escherichia coli. BIOTECHNIQUES 58:86-88(2015).
- Ponmani, T; Munavar, MH; et al. G(673) could be a novel mutational hot spot for intragenic suppressors of pheS5 lesion in Escherichia coli. MICROBIOLOGYOPEN 3:369-382(2014).
