FARP1
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Official Full Name
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -
Overview
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
FARP1;FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived);FERM, RhoGEF and pleckstrin domain-containing protein 1;CDEP;MGC87400;PLEKHC2;PPP1R75;protein phosphatase 1;regulatory subunit 75;Chondrocyte derived ezrin like protein;FERMRhoGEF and pleckstrin domain containing protein 1;FERM RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived);PH domain-containing family C member 2;chondrocyte-derived ezrin-like protein;protein phosphatase 1, regulatory subunit 75;pleckstrin homology domain-containing family C member 2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293T
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FARP1-3840H | Recombinant Human FARP1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FARP1-4537C | Recombinant Chicken FARP1 | Mammalian Cell | Chicken | His |
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| FARP1-5680M | Recombinant Mouse FARP1 Protein | Mammalian Cell | Mouse | His |
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| FARP1-596HCL | Recombinant Human FARP1 cell lysate | Human | Non |
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| Farp1-2954M | Recombinant Mouse Farp1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| FARP1-3117M | Recombinant Mouse FARP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FARP1-3117M-B | Recombinant Mouse FARP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FARP1-4709HF | Recombinant Full Length Human FARP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 129 amino acids |
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| FARP1-5822H | Recombinant Human FARP1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
FARP1 involved in several pathways and played different roles in them. We selected most pathways FARP1 participated on our site, such as Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of RhoA activity | ARHGAP4,ARHGEF18,ARHGEF25,ABR,AKAP13,ARAP1,ARHGEF10L,ARHGEF10,ARHGEF15,ARHGAP9 |
Protein Function
FARP1 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity,Rho guanyl-nucleotide exchange factor activity,cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FARP1 itself. We selected most functions FARP1 had, and list some proteins which have the same functions with FARP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal protein binding | MYPN,PKD2,ALDOB,MSNA,DES,CAPN2,ANXA2A,TOR1AIP1,PACSIN1,TPM1 |
| Rac guanyl-nucleotide exchange factor activity | FARP2,ARHGEF2,ALS2,PREX2,SPATA13,VAV3,VAV1,DOCK2,ARHGEF4 |
| Rho guanyl-nucleotide exchange factor activity | ARHGEF28,TRIO,SOS1,DCLRE1B,ARHGEF6,ARHGEF16,ARHGEF15,ARHGEF2,ARHGEF10,TIAM2 |
Interacting Protein
FARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FARP1.
PPP1CA;Trappc8;ssrna_ag;MYO1C;Flot1;PDGFRA;BRD2;CAPZA2;Flot2;Myh10;Pcbp2;Flnb;Prmt5;Prkar2a;SYNPO;Myh9;AKAP1;GEMIN7;GAR1
Resources
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References
- Fan, LF; Yan, HJ; et al. The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction. NEUROSCIENCE LETTERS 590:178-183(2015).
- Lopez, LM; Hill, WD; et al. Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities. STROKE 46:341-347(2015).
