FANCM
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Official Full Name
Fanconi anemia, complementation group M -
Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. [provided by RefSeq, Jul 2008] -
Synonyms
FANCM;Fanconi anemia, complementation group M;FAAP250;KIAA1596;Fanconi anemia group M protein;protein Hef ortholog;ATP-dependent RNA helicase FANCM;fanconi anemia-associated polypeptide of 250 kDa
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FANCM-3835H | Recombinant Human FANCM Protein, GST-tagged | Wheat Germ | Human | GST |
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| FANCM-5675M | Recombinant Mouse FANCM Protein | Mammalian Cell | Mouse | His |
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| FANCM-6367Z | Recombinant Zebrafish FANCM | Mammalian Cell | Zebrafish | His |
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| FANCM-595HCL | Recombinant Human FANCM cell lysate | Human | Non |
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| FANCM-3113M | Recombinant Mouse FANCM Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FANCM-3113M-B | Recombinant Mouse FANCM Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FANCM-4669HF | Recombinant Full Length Human FANCM Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 669 amino acids |
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Involved Pathway
FANCM involved in several pathways and played different roles in them. We selected most pathways FANCM participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | HES1,ZBTB32,UBE2T,DCLRE1A,REV1,FANCD2,POLI,TOP3A,ATRIP,WDR48 |
Protein Function
FANCM has several biochemical functions, for example, ATP binding,DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCM itself. We selected most functions FANCM had, and list some proteins which have the same functions with FANCM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nuclease activity | MEIOB,DOM3Z,RNASEKB,GDPD4,REXO4,DROSHA,EAR5,EXO5,RAD9,TMPPE |
| helicase activity | PIF1,EIF4A2,ERCC6L,EIF4A1,DQX1,MOV10B.1,DDX6,DDX19,IFIH1,CHD1L |
| ATP binding | SRX1,FYNA,NSFB,MAPK1,SEPHS1,CENPE,DDX28,SMC4,HSP70,P2RY1 |
| protein binding | DAK,GOLGA1,PDHX,NDUFS7,PGF,C22orf23,UNC45A,PRKACA,KCP,ALPI |
| chromatin binding | UXT,CENPB,ZFP143,SKI,CIC,HDAC5,HDAC2,NR5A5,KDM6B,CDCA5 |
| DNA binding | ZFP287,EHF,HMGA1A,HYPM,HOXC13,FOXE3,ZFML,TOX3,ZNF577,NR4A2A |
Interacting Protein
FANCM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCM here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCM.
TRIM27;APITD1;Cep85l;FANCA;MYC;Ppp2ca;FAAP100;CUL4B;Sass6;Ufl1;FANCB;TNRC6A;SORT1;KIFC3;PCIF1;CDKN2AIP
Resources
Related Services
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References
- Stoepker, C; Faramarz, A; et al. DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. DNA REPAIR 26:54-64(2015).
- Lorenz, A; Mehats, A; et al. Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination. NUCLEIC ACIDS RESEARCH 42:13723-13735(2014).
