FANCF
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Official Full Name
Fanconi anemia, complementation group F -
Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008] -
Synonyms
FANCF;Fanconi anemia, complementation group F;FAF;Fanconi anemia group F protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FANCF-28386TH | Recombinant Human FANCF | Wheat Germ | Human | Non | 91 amino acids |
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| FANCF-3831H | Recombinant Human FANCF Protein, GST-tagged | Wheat Germ | Human | GST |
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| FANCF-4248Z | Recombinant Zebrafish FANCF | Mammalian Cell | Zebrafish | His |
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| FANCF-6332HCL | Recombinant Human FANCF 293 Cell Lysate | HEK293 | Human | Non |
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| FANCF-4666HF | Recombinant Full Length Human FANCF Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 374 amino acids |
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Involved Pathway
FANCF involved in several pathways and played different roles in them. We selected most pathways FANCF participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | FANCG,POLH,DCLRE1A,EME1,ZBTB32,RMI2,FANCL,FANCM,USP1,SLX1B |
Protein Function
FANCF has several biochemical functions, for example, molecular_function,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCF itself. We selected most functions FANCF had, and list some proteins which have the same functions with FANCF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RAG1,UBE2B,ANKIB1,HACE1,ITCH,MED24,PPIL2,RFWD2,COP1,RNF126 |
| protein binding | POLM,HGF,PDCD4,ABI2,C10orf119,RRS1,RABIF,CUTC,WAS,TUBGCP3 |
| molecular_function | SCAMP4,WFDC15B,TSPAN35,TMEM20,C2orf28,GM1987,CAPN6,SAGB,TMEM117,CRYGM2D17 |
Interacting Protein
FANCF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCF here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCF.
FANCG;FANCA;SPTAN1;Hacd3;PPP5C;OLFM2;MARK3;aguA;FANCE
Resources
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References
- Synowiec, A; Szenajch, J; et al. The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer. GINEKOLOGIA POLSKA 86:150-154(2015).
- Arai, MA; Uemura, K; et al. Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa. MEDCHEMCOMM 6:455-460(2015).
