FAN1
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Official Full Name
FANCD2/FANCI-associated nuclease 1 -
Overview
Myotubularin related protein 15 (MTMR15) bears a coiled-coil and Rad18-type zinc finger domain. The function of MTMR15 remains uncharacterized; but it may play a role in DNA repair. Alternative names for MTMR15 include coiled-coil domain-containing protei -
Synonyms
FAN1;FANCD2/FANCI-associated nuclease 1;KIAA1018 , MTMR15, myotubularin related protein 15;fanconi-associated nuclease 1;myotubularin related protein 15;myotubularin-related protein 15;fanconi anemia associated nuclease 1;coiled-coil domain-contai
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Giant panda
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
- N-His&C-Myc
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FAN1-4133Z | Recombinant Zebrafish FAN1 | Mammalian Cell | Zebrafish | His |
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| FAN1-5666M | Recombinant Mouse FAN1 Protein | Mammalian Cell | Mouse | His |
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| FAN1-911HCL | Recombinant Human FAN1 cell lysate | Human | Non |
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| FAN1-3109M | Recombinant Mouse FAN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FAN1-3109M-B | Recombinant Mouse FAN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FAN1-564G | Recombinant Giant panda FAN1 protein, His&Myc-tagged | E.coli | Giant panda | N-His&C-Myc | 898-1025aa |
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| Fan1-6332M | Recombinant Mouse Fan1 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 893-1020a.a. |
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Involved Pathway
FAN1 involved in several pathways and played different roles in them. We selected most pathways FAN1 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | FANCF,PMS2,RAD51C,RMI2,FANCE,FANCL,POLI,HER9,FANCG,PALB2 |
Protein Function
FAN1 has several biochemical functions, for example, 5-3 exonuclease activity,5-flap endonuclease activity,flap-structured DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAN1 itself. We selected most functions FAN1 had, and list some proteins which have the same functions with FAN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 5-flap endonuclease activity | FEN1,DNA2,SLX1B |
| 5-3 exonuclease activity | DCLRE1C,DOM3Z,DXO,CPSF3,POLN,EXO1,FEN1,XRN2 |
| magnesium ion binding | ATP8A1,PKMB,TSSK6,NT5C3B,ATP9A,PPM1N,SNRK,ENO3,PKLR,PRTFDC1 |
| ubiquitin binding | TSG101,UCHL3,PER2,UBXN2A,USP25,SIRT2,CRY1,UBXN11,NEDD4,SPRTN |
| protein binding | PPP1R8,PPP3CB,ALOX12,MYL12B,FCER1G,C6orf130,SEC24D,PAFAH1B1,TFF2,BCAM |
| phosphodiesterase I activity | ENPP1,ENPP2,APEX1 |
Interacting Protein
FAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FAN1.
b4dt77_human;PPP2R1A;PIK3C2B;PSMD11;SUPT5H;AKR7A2;AP2A2;SDPR;HEXA;MLH1;PMS1;PMS2;HIST1H3D;TRAP1;PRPF4B;FSCN1;ANKLE2;WDR75;MIER1
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References
- Yan, PX; Huo, YG; et al. Crystal structure of human Fanconi-associated nuclease 1. PROTEIN & CELL 6:225-228(2015).
- Zhao, Q; Xue, XY; et al. Structural insights into 5 ' flap DNA unwinding and incision by the human FAN1 dimer. NATURE COMMUNICATIONS 5:-(2014).
