FAM125B
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Official Full Name
family with sequence similarity 125, member B -
Overview
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
FAM125B;family with sequence similarity 125, member B;C9orf28, chromosome 9 open reading frame 28;multivesicular body subunit 12B;FLJ00001;C9orf28;Chromosome 9 open reading frame 28;ESCRT-I complex subunit MVB12B;F125B_HUMAN;Family with sequence similarity 125 member B;Protein FAM125B;MVB12B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FAM125B-5484M | Recombinant Mouse FAM125B Protein | Mammalian Cell | Mouse | His |
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| FAM125B-6437HCL | Recombinant Human FAM125B 293 Cell Lysate | HEK293 | Human | Non |
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| FAM125B-2977M | Recombinant Mouse FAM125B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FAM125B-2977M-B | Recombinant Mouse FAM125B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
FAM125B involved in several pathways and played different roles in them. We selected most pathways FAM125B participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAM125B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | CHMP5B,ARFGAP1,EEA1,GRK1A,CDC42,IGF1RA,ZFYVE9,RAB11FIP4A,RAB11FIP3,CAV3 |
Protein Function
FAM125B has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,procollagen galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FAM125B itself. We selected most functions FAM125B had, and list some proteins which have the same functions with FAM125B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP11B2,CYP2K22,CYP2AD3,CYP2X8,LEPRE1,CYP2AA2,BBOX1,PHF8,HBB-BH1,PLOD3 |
| L-ascorbic acid binding | PLOD1,P4HA2,PHYH,EGLN1B,PAM,P4HTM,P4HA1B,ALKBH3,OGFOD1,TMLHE |
| protein binding | TBX24,HIST1H4B,GSTA2,C9orf116,SNRPD1,TRIAP1,BFSP1,IGF2,RGS8,TRMT12 |
| procollagen-lysine 5-dioxygenase activity | PLOD1A,PLOD2,PLOD1,PLOD3 |
| procollagen glucosyltransferase activity | PLOD3 |
| procollagen galactosyltransferase activity | PLOD3,COLGALT2,GLT25D1,GLT25D2 |
Interacting Protein
FAM125B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAM125B here. Most of them are supplied by our site. Hope this information will be useful for your research of FAM125B.
LNX1;P/V/C
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