FAM123B
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Official Full Name
family with sequence similarity 123B -
Overview
WTX (Wilms' tumor gene on the X chromosome) is a developmentally regulated gene with a potentially important role in kidney development (1). Functional studies of WTX suggest that it acts as a tumor suppressor gene in renal cells by promoting beta-catenin -
Synonyms
FAM123B;family with sequence similarity 123B;APC membrane recruitment protein 1;adenomatous polyposis coli membrane recruitment 1;AMER1;FLJ39827;RP11 403E24.2;Wilms Tumor on the X;WTX;protein FAM123B;Wilms tumor gene on the
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FAM123B-5479M | Recombinant Mouse FAM123B Protein | Mammalian Cell | Mouse | His |
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| FAM123B-2973M | Recombinant Mouse FAM123B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FAM123B-2973M-B | Recombinant Mouse FAM123B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
FAM123B involved in several pathways and played different roles in them. We selected most pathways FAM123B participated on our site, such as Beta-catenin phosphorylation cascade,Degradation of beta-catenin by the destruction complex,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAM123B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Beta-catenin phosphorylation cascade | CSNK1A1 |
| Signaling by Wnt | ROR1,SOX4A,RSPO3,SOX13,SRY,PRICKLE1,SOX4B,LGR6,SOX32,TLE3B |
| Signal Transduction | CRABP2,KIF7,PRICKLE1B,GDI2,OXER1,PAG1,FGFBP1,DNER,SHARPIN,ARHGAP23 |
| Degradation of beta-catenin by the destruction complex | CTBP1,TLE2,CTBP2,TLE3,TLE1,AES,TLE3B,TLE4 |
Protein Function
FAM123B has several biochemical functions, for example, beta-catenin binding,lipid binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAM123B itself. We selected most functions FAM123B had, and list some proteins which have the same functions with FAM123B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid binding | PACSIN3,PTGS2,FAM123C,GPIHBP1,CYP21A1,BPIFB1,PAQR7B,SH3GL2,STARD7,RBP2A |
| phosphatidylinositol-4,5-bisphosphate binding | MARK1,RAG2,KLHL8,VIL1,SESTD1,MYO1G,TULP3,ASAP1,ACTN2,FAM21C |
| beta-catenin binding | TBL1X,CTNNA1,SHROOM2,CTNNBIP1,CALCOCO1,CDH5,KLF4,CDH1,AXIN2,TAX1BP3 |
Interacting Protein
FAM123B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAM123B here. Most of them are supplied by our site. Hope this information will be useful for your research of FAM123B.
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References
- Kriz, V; Pospichalova, V; et al. beta-Arrestin Promotes Wnt-induced Low Density Lipoprotein Receptor-related Protein 6 (Lrp6) Phosphorylation via Increased Membrane Recruitment of Amer1 Protein. JOURNAL OF BIOLOGICAL CHEMISTRY 289:1128-1141(2014).
- Holman, SK; Morgan, T; et al. Osteopathia striata congenita with cranial sclerosis and intellectual disability due to contiguous gene deletions involving the WTX locus. CLINICAL GENETICS 83:251-256(2013).
