EYA4
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Official Full Name
eyes absent homolog 4 -
Overview
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
EYA4;eyes absent homolog 4 (Drosophila);CMD1J, DFNA10, eyes absent (Drosophila) homolog 4;eyes absent homolog 4;dJ78N10.1 (eyes absent);CMD1J;DFNA10
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EYA4-3595H | Recombinant Human EYA4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EYA4-8371Z | Recombinant Zebrafish EYA4 | Mammalian Cell | Zebrafish | His |
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| EYA4-6490HCL | Recombinant Human EYA4 293 Cell Lysate | HEK293 | Human | Non |
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| EYA4-4459HF | Recombinant Full Length Human EYA4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 616 amino acids |
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Involved Pathway
EYA4 involved in several pathways and played different roles in them. We selected most pathways EYA4 participated on our site, such as DNA Double Strand Break Response,DNA Double-Strand Break Repair,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | POLI,UIMC1,DDB2,KIAA1530,ALKBH2,COPS4,BABAM1,DDB1,TDP2,APITD1 |
| DNA Double-Strand Break Repair | BAZ1B,TDP1,TIMELESS,RAD9,RAD1,GEN1,PARP1,PPP4R2,PPP4CB,EYA3 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | EYA3,KDM4A,KDM4B,EYA2,BAZ1B |
| DNA Double Strand Break Response | SMARCA5,THRSP,HTATIP,CHEK2,RNF168,RAD50,EYA3,BABAM1,KDM4B,FAM175A |
Protein Function
EYA4 has several biochemical functions, for example, metal ion binding,protein binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA4 itself. We selected most functions EYA4 had, and list some proteins which have the same functions with EYA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZFP410,CLCA1,C22orf28,ZNF285A,ANTXR2,SALL3,HDAC8,ATP13A5,TGM5,POLD1 |
| protein tyrosine phosphatase activity | PTPRC,DUSP23A,PTPN20B,DUSP5,PTPN9,CDC14B,PTPRG,PTPN2A,DUSP22,DUSP13 |
| protein binding | GNAT1,CDKN1C,CLOCKB,MAGOHB,SHC1,RXRA,DNTT,CCDC141,BCAM,UBL7 |
Interacting Protein
EYA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA4.
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References
- Tan, MX; Shen, XF; et al. Identification of I411K, a novel missense EYA4 mutation causing autosomal dominant non-syndromic hearing loss. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1467-1472(2014).
- Hou, X; Peng, JX; et al. DNA Methylation Profiling Identifies EYA4 Gene as a Prognostic Molecular Marker in Hepatocellular Carcinoma. ANNALS OF SURGICAL ONCOLOGY 21:3891-3899(2014).
