EYA1

  • Official Full Name

    eyes absent homolog 1 (Drosophila)

  • Overview

    This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.

  • Synonyms

    EYA1;eyes absent homolog 1 (Drosophila);BOR, eyes absent (Drosophila) homolog 1;eyes absent homolog 1;BOP;BOR;EYA1_HUMAN;eyes absent 1;eyes absent 1 homolog;eyes absent homolog1;MGC141875
Cat.# Product name Source (Host) Species Tag Protein Length Price
EYA1-26641TH Recombinant Human EYA1 Wheat Germ Human Non 71 amino acids
EYA1-3590H Recombinant Human EYA1 Protein, GST-tagged Wheat Germ Human GST
EYA1-48H Recombinant Human EYA1 protein E.coli Human Non 592aa
EYA1-8797Z Recombinant Zebrafish EYA1 Mammalian Cell Zebrafish His
EYA1-6492HCL Recombinant Human EYA1 293 Cell Lysate HEK293 Human Non
EYA1-4456HF Recombinant Full Length Human EYA1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 470 amino acids

    Involved Pathway

    EYA1 involved in several pathways and played different roles in them. We selected most pathways EYA1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer ASPSCR1,MMP9,TSPAN7,Aff1,PFTK1,ETV4,FUS,PRCC,MAF,PBX3

    Protein Function

    EYA1 has several biochemical functions, for example, RNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA1 itself. We selected most functions EYA1 had, and list some proteins which have the same functions with EYA1. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine phosphatase activity DUSP19,DUSP13A,PTPN4A,MTMR3,MDP1,CDC25C,DUSP14,DUSP3B,DUSP3,EYA2
    metal ion binding SIRT4,MEP1A.2,CSH2,CYB5R4,MAT2AL,RNF187,NR5A1B,MICALL2,Car4,RUNX1T1
    protein binding MMP14,TP73,RCN3,LAIR1,SDCBP2,C16orf5,ZYX,CXCR5,HBP1,CBX7
    RNA binding NOM1,UPF1,FXR2,LSM5,HNRNPA1L2,BICC1,TERT,CELF6,RPS4Y1,MIF4GD

    Interacting Protein

    EYA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA1.

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