EXT2
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Official Full Name
exostosin 2 -
Overview
EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. -
Synonyms
EXT2;exostosin 2;exostoses (multiple) 2;exostosin-2;Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase;N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase;SOTV;multiple exostoses protein 2;putative tumor suppressor protein EXT2;N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase;glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Mus musculus
- Bovine
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXT2-12604H | Recombinant Human EXT2, GST-tagged | E.coli | Human | GST | C-term-350a.a. | |
| EXT2-1866Z | Recombinant Zebrafish EXT2 | Mammalian Cell | Zebrafish | His |
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| EXT2-3003C | Recombinant Chicken EXT2 | Mammalian Cell | Chicken | His |
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| EXT2-3585H | Recombinant Human EXT2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EXT2-5392M | Recombinant Mouse EXT2 Protein | Mammalian Cell | Mouse | His |
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| EXT2-6496HCL | Recombinant Human EXT2 293 Cell Lysate | HEK293 | Human | Non |
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| EXT2-1446H | Recombinant Human EXT2 Protein, His-tagged | E.coli | Human | His | Pro47-Phe253 |
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| EXT2-2909M | Recombinant Mouse EXT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EXT2-2909M-B | Recombinant Mouse EXT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EXT2-4447HF | Recombinant Full Length Human EXT2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 718 amino acids |
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| RFL14814MF | Recombinant Full Length Mouse Exostosin-2(Ext2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-718) |
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| RFL3632BF | Recombinant Full Length Bovine Exostosin-2(Ext2) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-718) |
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Involved Pathway
EXT2 involved in several pathways and played different roles in them. We selected most pathways EXT2 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | EXT1C,HS3ST3B1B,HS6ST1,MAPK1IP1L,NDST1,NDST2,EXTL3,XYLT2,EXT1A,HS3ST1L1 |
| Metabolic pathways | HLCS,RDH10A,GMPS,CYP19A1A,CDIPT,FAM213B,TPI1,MT-ND4,NDUFAB1A,POLR3F |
Protein Function
EXT2 has several biochemical functions, for example, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity,contributes_to acetylglucosaminyltransferase activity,glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXT2 itself. We selected most functions EXT2 had, and list some proteins which have the same functions with EXT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity, transferring glycosyl groups | POC1BL,B3GALTL,B3GALT6,ST6GALNAC1.2,B3GNT7L,4931440L10Rik,ST6GALNAC5B,B3GALTLA,PNP5B,DPAGT1 |
| NOT protein homodimerization activity | NUDT16L1,DDIT3,MLXIPL,MSH3,MECOM,KCNA3,MSH6,MYO9B |
| heparan sulfate N-acetylglucosaminyltransferase activity | EXT1 |
| glucuronosyltransferase activity | UGT2A1,UGT5B3,UGT1A6B,CSGALNACT1,UGT1B3,UGT5A3,UGT5C1,UGT2B7,UGT5F1,UGT1A7 |
| metal ion binding | CYP19A1A,THAP4,ITGA1,KLF1,ZFYVE21,CDH15,HE1B,BTR02,RASAL1,ARFGAP2 |
| N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity | EXT1C,EXT1,EXT1B,EXT1A |
| protein heterodimerization activity | NEFH,TERF1,HER5,H2-AA,UGT1A1,KATNB1,CYBA,PML,RRAGA,HIST1H4I |
| glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | EXT1,EXTL1,EXT1B,EXT1A,EXT1C |
Interacting Protein
EXT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXT2.
STK16;SNCG;FABP4;CNTF;HNF4A;RPS29;CRB1;TCEB1;HYOU1;SLC22A2;PFDN1;TK1;ANXA7;CDKN1A;SMN1;yapA;GSKIP
Resources
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References
- Nadanaka, S; Kagiyama, S; et al. Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. BIOCHEMICAL JOURNAL 454:133-145(2013).
- Multhaupt, HAB; Couchman, JR; et al. Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:908-915(2012).
