EXOSC9
-
Official Full Name
exosome component 9 -
Overview
This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. -
Synonyms
EXOSC9;exosome component 9;PMSCL1, polymyositis/scleroderma autoantigen 1, 75kDa;exosome complex component RRP45;p5;p6;PM/Scl 75;polymyositis/scleroderma autoantigen 1 (75kD);RRP45;Rrp45p;autoantigen PM/Scl 1;PMSCL autoantigen, 75kD;exosome c
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Baculovirus
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Insect Cells
- His
- GST
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
EXOSC9 involved in several pathways and played different roles in them. We selected most pathways EXOSC9 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | PABPC1A,CNOT3,PFKMA,CNOT7,EXOSC3,C1D,CNOT2,DDX6,LSM8,XRN1 |
Protein Function
EXOSC9 has several biochemical functions, for example, AU-rich element binding,RNA binding,exonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC9 itself. We selected most functions EXOSC9 had, and list some proteins which have the same functions with EXOSC9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | RPL21,ADARB1A,ILF3B,CSTF2,WRAP53,HNRPL,CSTF3,RC3H2,EIF4G2B,ALYREF |
| nuclease activity | CNOT6L,RNASEKA,SND1,ENDOU2,RNASEL3,CNOT6,TMPPE,FANCM,EAR1,RNASEL2 |
| poly(A) RNA binding | GRN,DNTTIP2,STAU1,TBL3,DMGDH,CCDC108,NAP1L1,RPS3A,SRRT,PRPF4B |
| AU-rich element binding | NUDT21,EXOSC7,HNRNPA0,EXOSC8,ELAVL4,ELAVL1,APOBEC1,CPSF5,EXOSC4,TIAL1 |
| exonuclease activity | LOC81691,DOM3Z,REXO4,WRN,EXO5,REXO1,FEN1,XRN1,REX1,AEN |
| hydrolase activity | DESI2,MBLAC2,PPP4CB,TMPRSS11F,PL10,SYNJ1,IRGC,LCTLB,PRSS28,PRSS44 |
Interacting Protein
EXOSC9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC9 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC9.
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References
- Egan, ED; Braun, CR; et al. Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex. RNA-A PUBLICATION OF THE RNA SOCIETY 20:867-881(2014).
- Oya, E; Kato, H; et al. Mediator Directs Co-transcriptional Heterochromatin Assembly by RNA Interference-Dependent and -Independent Pathways. PLOS GENETICS 9:-(2013).
