EXOSC8
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Official Full Name
exosome component 8 -
Overview
This gene encodes a 3-5 exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. -
Synonyms
EXOSC8;exosome component 8;exosome complex component RRP43;bA421P11.3;CBP interacting protein 3;CIP3;EAP2;OIP2;Opa interacting protein 2;p9;RRP43;Rrp43p;OIP-2;CBP-interacting protein 3;opa-interacting protein 2;exosome complex exonuclease R
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
EXOSC8 involved in several pathways and played different roles in them. We selected most pathways EXOSC8 participated on our site, such as ATF4 activates genes,Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA,Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | LSM8,CNOT2,CNOT8,ZCCHC7,TOB1,LSM3,EDC3,DCP1A,DIS3,DCP1B |
| Deadenylation-dependent mRNA decay | EIF4A1,LSM6,C2orf29,EIF4E,DCP1B,D1BWG0212E,EIF4G1,TNKS1BP1,EIF4EB,PAIP1 |
| Metabolism of proteins | MAN1A2,KLHDC3,PFDN6,SEC22C,HYOU1,ARSF,GZMH,MUC20,MUC13,PREB |
| Gene Expression | CBX3A,ZNF707,RRN3,POLR3G,POP1,CPSF4,PSTPIP2,MTA3,BRF1,SKI |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | ZFP36L1,MAPKAPK2B,DCP2,ZFP36L1A,ZFP36L1B |
| PERK regulates gene expression | DCP2 |
| KSRP (KHSRP) binds and destabilizes mRNA | DCP2,KHSRP |
| ATF4 activates genes | DDIT3,KCNA3,DCP2 |
Protein Function
EXOSC8 has several biochemical functions, for example, AU-rich element binding,NOT exoribonuclease activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC8 itself. We selected most functions EXOSC8 had, and list some proteins which have the same functions with EXOSC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AU-rich element binding | ZFP36,EXOSC9,ZFP36L3,TIA1,APOBEC1,HNRNPA0,CPSF5,ELAVL1,ZFP36L1,EXOSC4 |
| poly(A) RNA binding | CSTF3,HLTF,NOL12,NUDT21,PRAC,MYEF2,HSP90AA1,TSR1,CCBL2,RBM26 |
| NOT exoribonuclease activity | EXOSC2,EXOSC5,EXOSC3,EXOSC4,EXOSC1,EXOSC7 |
| protein binding | PLP2,NCOA5,MAPK15,BCL2L13,CBLL1,C19orf46,METTL17,TBC1D20,IL15RA,FAM134C |
Interacting Protein
EXOSC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC8.
EXOSC5;EXOSC3;EXOSC2;DIS3L;9098
Resources
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References
- Eggens, VRC; Barth, PG; et al. EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations. ORPHANET JOURNAL OF RARE DISEASES 9:-(2014).
- Lim, SJ; Boyle, PJ; et al. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. NUCLEIC ACIDS RESEARCH 41:2963-2980(2013).
