EXOSC10
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Official Full Name
Exosome Component 10 -
Overview
Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis. -
Synonyms
EXOSC10;exosome component 10;p3;p4;RRP6;PMSCL;Rrp6p;PM-Scl;PMSCL2;PM/Scl-100;OTTHUMP00000002176;OTTHUMP00000002177;autoantigen PM-SCL;autoantigen PM/Scl 2;polymyositis/scleroderma autoantigen 100 kDa;polymyositis/scleroderma autoantigen 2 (100kD);polymyositis/scleroderma autoantigen 2, 100kDa;P100 polymyositis-scleroderma overlap syndrome-associated autoantigen;EXOSX_HUMAN;p2;PM Scl;PM/Scl 100
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXOSC10-12594H | Recombinant Human EXOSC10, GST-tagged | E.coli | Human | GST | C-term-300a.a. | |
| EXOSC10-3475H | Recombinant Human EXOSC10 protein, His-tagged | E.coli | Human | His | 586-885 aa | |
| EXOSC10-11312Z | Recombinant Zebrafish EXOSC10 | Mammalian Cell | Zebrafish | His |
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| EXOSC10-183H | Recombinant human EXOSC10 | E.coli | Human | His |
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| EXOSC10-1995C | Recombinant Chicken EXOSC10 | Mammalian Cell | Chicken | His |
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| EXOSC10-26640TH | Recombinant Human EXOSC10, His-tagged | Human | His | Full L. |
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| EXOSC10-3567H | Recombinant Human EXOSC10 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EXOSC10-5381M | Recombinant Mouse EXOSC10 Protein | Mammalian Cell | Mouse | His |
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| EXOSC10-5391H | Recombinant Human EXOSC10 protein, His-tagged | Insect Cell | Human | His |
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| EXOSC10-6504HCL | Recombinant Human EXOSC10 293 Cell Lysate | HEK293 | Human | Non |
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| EXOSC10-2815H | Recombinant Human EXOSC10 protein(691-850 aa), C-His-tagged | E.coli | Human | His | 691-850 aa |
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| EXOSC10-2902M | Recombinant Mouse EXOSC10 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EXOSC10-2902M-B | Recombinant Mouse EXOSC10 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EXOSC10-4426HF | Recombinant Full Length Human EXOSC10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 885 amino acids |
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Involved Pathway
EXOSC10 involved in several pathways and played different roles in them. We selected most pathways EXOSC10 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | PATL1,TTC37,ENO1,DnaK,PABPC1A,PAN2,PFKM,DHX36,HSPA9,BTG2 |
Protein Function
EXOSC10 has several biochemical functions, for example, 3-5 exonuclease activity,exoribonuclease activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC10 itself. We selected most functions EXOSC10 had, and list some proteins which have the same functions with EXOSC10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exoribonuclease activity | CNOT6,CNOT7 |
| protein binding | EPB41L1,FANCI,UBA52,MYL6B,KIR2DL3,RNF115,PLIN3,ISL1,UBXN1,TTC33 |
| nucleotide binding | ABCA1B,U2AF2B,GNAI2A,PPIE,HRASB,ARF3B,FPGS,PLK2B,ORC4,ATP1A1A.3 |
| poly(A) RNA binding | YTHDF2,SRSF7,GNL3,TRMT6,STRAP,C14orf93,PUF60,HNRNPH2,TWF2,MRPL54 |
| 3-5 exonuclease activity | RAD9,RAD9B,RAD9A,APEX1,MRE11A,TREX1,RAD1,POLG,EXD1,ERI1 |
Interacting Protein
EXOSC10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC10 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC10.
EXOSC2;MPHOSPH6;EXOSC5;EXOSC4;DIS3
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