EXOG
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Official Full Name
endo/exonuclease (5-3), endonuclease G-like -
Overview
This gene encodes an endo/exonuclease with 5-3 exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5 end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. -
Synonyms
EXOG;endo/exonuclease (5-3), endonuclease G-like;ENDOGL1, ENDOGL2, endonuclease G like 1 , endonuclease G like 2;nuclease EXOG, mitochondrial;ENGL;ENGL a;ENGL b;endo G-like 1;endonuclease G-like 1;endonuclease G-like 2;ENGLA;ENGLB;ENGL-a;EN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXOG-12592H | Recombinant Human EXOG, GST-tagged | E.coli | Human | GST | C-term-228a.a. | |
| EXOG-12593H | Recombinant Human EXOG protein, His-tagged | E.coli | Human | His | 228 | |
| EXOG-3565H | Recombinant Human EXOG Protein, GST-tagged | Wheat Germ | Human | GST |
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| EXOG-6506HCL | Recombinant Human EXOG 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
EXOG involved in several pathways and played different roles in them. We selected most pathways EXOG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
EXOG has several biochemical functions, for example, endonuclease activity,metal ion binding,nuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOG itself. We selected most functions EXOG had, and list some proteins which have the same functions with EXOG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endonuclease activity | DNASE1L3L,PMS2,EME2,ANG3,RNASE4,RNASE2,G3BP1,EAR2,RSFR,FEN1 |
| nucleic acid binding | CHD6,ZBTB8B,ZFP553,ZFP523,ZFP276,ZBED6,SETD1BA,C19orf6,JAZF1B,ARIH2 |
| nuclease activity | ANG4,RNASEKA,USB1,RNASEL4,TMPPE,MRE11A,DROSHA,TDP2,DNASE1L3L,TDP2B |
| metal ion binding | SETDB1B,ZDHHC16A,KALRN,MCEE,FCNA,ZNF726,S100A10A,ZNF200,TRIM43A,CSHL1 |
Interacting Protein
EXOG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOG here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOG.
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References
- Tigchelaar, W; Yu, HJ; et al. Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C155-C163(2015).
- Szczesny, B; Brunyanszki, A; et al. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. NUCLEIC ACIDS RESEARCH 42:13161-13173(2014).
