EXOC5
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Official Full Name
exocyst complex component 5 -
Overview
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. -
Synonyms
EXOC5;exocyst complex component 5;SEC10 (S. cerevisiae) like 1 , SEC10 like 1 (S. cerevisiae) , SEC10L1;SEC10;SEC10P;AI448003;Gm76;HSEC10;PRO1912;AI447711;Exocyst complex component Sec10;p71 component of rsec6/8 secretory complex;SEC10L1;SEC10-like 1
Recombinant Proteins
- Rhesus macaque
- Chicken
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
EXOC5 involved in several pathways and played different roles in them. We selected most pathways EXOC5 participated on our site, such as Arf6 trafficking events,Assembly of the primary cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | RP2,IFT81,TRIP11,GABPB1,RABL5,TCTEX1D2,TTC30A,EXOC1,MRPL10,CLUAP1 |
| Insulin processing | SLC30A5,EXOC1,PCSK2,CPE,RAB27A,EXOC3,SLC30A6,EXOC8,KIF5A,KIF5B |
| Insulin Pathway | EXOC6,EXOC3,GRB10,DOK1,GRB14,EXOC1 |
| Assembly of the primary cilium | IFT22,ACTR1A,CEP78,SDCCAG8,TTC8,ARF4A,TCTN1,CLASP1,CNGA2,B9D2 |
| Membrane Trafficking | PICALM,ARCN1A,MYO6,BLOC1S3,DAB2,GJB3,GJA5,TMED2,NAPB,CNO |
| Arf6 trafficking events | EDNRB,DNM2,JUP,CPE,ADRB2,SCAMP2,EXOC3,CLTC,CTNND1,CTNNA1 |
| Metabolism of proteins | FURINB,DDX11,NOP56,SEC22A,PPP6C,IGFBP5A,EID3,THSD7A,MAN1B1,TIMM13 |
| Cargo trafficking to the periciliary membrane | EXOC6,RAB3IP,CCT3,CCT8,BBS2,EXOC3,BBS12,RHOL,PROL1,CCT2 |
Protein Function
EXOC5 has several biochemical functions, for example, Ral GTPase binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC5 itself. We selected most functions EXOC5 had, and list some proteins which have the same functions with EXOC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | FEZ1,PDLIM5,SLC6A3,MAP2K1,RBPJ,APTX,PPP1CC,MECP2,ERCC2,TARBP2 |
| Ral GTPase binding | PRKCH,FLNA,RNF41,RAB34,LSM2,MYO1C,EXOC8,USP33,RALBP1,EXOC4 |
Interacting Protein
EXOC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC5.
TNPO2;PRKCG;CDH2;SOX10;ICA1;ADCK1;ACTR3B;TBX21;pi3p;15-deoxy-delta(12,14;SNW1;CDC5L
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References
- Liu, DM; Novick, P; et al. Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. JOURNAL OF CELL BIOLOGY 207:59-72(2014).
- Tanaka, T; Iino, M; et al. Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. CELLULAR SIGNALLING 26:2071-2085(2014).
