EXOC4
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Official Full Name
exocyst complex component 4 -
Overview
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
EXOC4;exocyst complex component 4;SEC8 like 1 (S. cerevisiae) , SEC8L1;KIAA1699;MGC27170;REC8;SEC8;Sec8p;dSec8;EXOC 4;EXOC4_HUMAN;Exocyst complex component Sec8;REC 8;rSec 8;Sec 8;Sec 8p;SEC8 like 1;SEC8 protein;Sec8L1;SEC8-like 1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HIS
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXOC4-137H | Recombinant Human EXOC4 Protein, HIS-tagged | E.coli | Human | HIS |
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| EXOC4-2167R | Recombinant Rat EXOC4 Protein | Mammalian Cell | Rat | His |
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| EXOC4-3256Z | Recombinant Zebrafish EXOC4 | Mammalian Cell | Zebrafish | His |
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| EXOC4-4261C | Recombinant Chicken EXOC4 | Mammalian Cell | Chicken | His |
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| EXOC4-5373M | Recombinant Mouse EXOC4 Protein | Mammalian Cell | Mouse | His |
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| EXOC4-6510HCL | Recombinant Human EXOC4 293 Cell Lysate | HEK293 | Human | Non |
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| EXOC4-6511HCL | Recombinant Human EXOC4 293 Cell Lysate | HEK293 | Human | Non |
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| EXOC4-1824R | Recombinant Rat EXOC4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| EXOC4-1824R-B | Recombinant Rat EXOC4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| EXOC4-2896M | Recombinant Mouse EXOC4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EXOC4-2896M-B | Recombinant Mouse EXOC4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
EXOC4 involved in several pathways and played different roles in them. We selected most pathways EXOC4 participated on our site, such as Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | CDC42L2,ACTN2,CLDN15LA,PRKCHA,LLGL2,MYH9A,PPP2R1B,CLDN17,PARD6GB,YBX3 |
Protein Function
EXOC4 has several biochemical functions, for example, PDZ domain binding,Ral GTPase binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC4 itself. We selected most functions EXOC4 had, and list some proteins which have the same functions with EXOC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | KCNQ2,RELA,SNCA,APTX,TGFB1,DCN,HAX1,MAP2K1,TAF11,GTF2H3 |
| protein binding | PPP5C,SPOP,C12orf49,FYN,CDON,PIH1D3,SPRR1A,TIE1,ORM1,CYHR1 |
| PDZ domain binding | PROSAPIP1,ATP2B3B,GRIK5,CIT,SDC2,F11R,DOCK4,PTENA,TBC1D10A,PLEKHA1 |
| Ral GTPase binding | USP33,EXOC8,RALBP1,MYO1C,PIH1D2,RNF41,LSM2,PRKCH,RAB34,FLNA |
Interacting Protein
EXOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC4.
SPAG9;BIRC6;LAPTM4B;EGFR;nef;WASH1;MYC;BECN1;NFKBIB;Poc1b;Atg5;DTNBP1;EXOC1
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References
- Zuo, XF; Zhang, J; et al. Exo70 interacts with the Arp2/3 complex and regulates cell migration. NATURE CELL BIOLOGY 8:1383-U38(2006).
