ETV6
-
Official Full Name
ets variant 6 -
Overview
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] -
Synonyms
ETV6;ets variant 6;TEL;TEL/ABL;transcription factor ETV6;TEL1 oncogene;ETS-related protein Tel1;ETS translocation variant 6;ets variant gene 6 (TEL oncogene)
Recombinant Proteins
- Rhesus macaque
- Human
- Chicken
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ETV6 involved in several pathways and played different roles in them. We selected most pathways ETV6 participated on our site, such as Dorso-ventral axis formation,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETV6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dorso-ventral axis formation | NOTCH1B,NOTCH1A,SOS1,NOTCH1,CPEB2,PIWIL1,GRB2B,CPEB1A,PIWIL2,PPP1R2P9 |
| Transcriptional misregulation in cancer | NTRK1,SIN3A,PAX3,TRAF1,MMP3,LYL1,ELANE,GZMB,RELA,TP53 |
Protein Function
ETV6 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETV6 itself. We selected most functions ETV6 had, and list some proteins which have the same functions with ETV6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MITFB,OTX2,IRF1,ZFP292,HEYL,TP53,HOXC11,FOXK2,FOSB,SOX4 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | GATA1,RBPJA,RELA,PDX1,NFE2L3,SMAD3,FOXA2,HOXA2,PGR,ZNF695 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ATF5A,GATA1A,GLIS1,PHOX2A,DMBX1,RFX6,ZNF561,H2AFY2,NKX2-1,TBX5 |
| protein domain specific binding | HIST1H4I,CA,LIN7C,MLF1,OSBP,WHRN,SP100,CHMP1A,TFDP2,YWHAZ |
| transcription factor activity, sequence-specific DNA binding | TCF7L1B,NFE2L2,CSRNP2,RARGA,NFAT5,FOXG1A,DMRT2A,NFE2L3,MYT1,MYOG |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | ETV3,NPAS1,FOXC1,ZNF202,TFAP2E,ATF4B2,FLI1,TFDP3,MEF2D,SOX30 |
| protein binding | MYOZ2,MDM2,PCDH18,POLR1A,PUM2,FAM113A,STARD10,FRAS1,ZFP523,PPIE |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | FOXO3,ARID5B,ZBTB12.2,E2F7,BCL6,MNT,VAX2,POU5F1,ZC3H8,PCGF6 |
Interacting Protein
ETV6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETV6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETV6.
WDYHV1;AP1M1;HDAC9;HDAC9;HDAC9;HDAC9;UBE2I;q81la6_bacan;fldB;MYC;SNW1;VPS26B;USP7
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References
- Manda, SS; Nirujogi, RS; et al. Identification and Characterization of Proteins Encoded by Chromosome 12 as Part of Chromosome-centric Human Proteome Project. JOURNAL OF PROTEOME RESEARCH 13:3166-3177(2014).
- Linka, Y; Ginzel, S; et al. The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. BLOOD CANCER JOURNAL 3:-(2013).
