ETS2

  • Official Full Name

    v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

  • Overview

    This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded;protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is;located on the X chromosome. Alternative splicing results in multiple transcript variants.

  • Synonyms

    ETS2;v-ets erythroblastosis virus E26 oncogene homolog 2 (avian);v ets avian erythroblastosis virus E26 oncogene homolog 2;protein C-ets-2;C ets 2 protein;ETS2_HUMAN;ETS2IT1;Oncogene ETS2;v ets avian erythroblastosis virus E2 oncogene homolog 2;V ets erythroblastosis virus E26 oncogene homolog 2;oncogene ETS-2;v-ets avian erythroblastosis virus E2 oncogene homolog 2;v-ets avian erythroblastosis virus E26 oncogene homolog 2

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ETS2-12569H Recombinant Human ETS2, GST-tagged E.coli Human GST 84-444a.a.
ETS2-0423H Recombinant Human ETS2 protein, His-tagged E.coli Human His 84-444 aa
ETS2-247H Recombinant Human ETS2, His-tagged E.coli Human His 1-469aa
ETS2-2948Z Recombinant Zebrafish ETS2 Mammalian Cell Zebrafish His
ETS2-3529H Recombinant Human ETS2 Protein, GST-tagged Wheat Germ Human GST
ETS2-5348M Recombinant Mouse ETS2 Protein Mammalian Cell Mouse His
ETS2-6864C Recombinant Chicken ETS2 Mammalian Cell Chicken His
ETS2-902H Recombinant Human ETS2 Protein, His-tagged E.coli Human His
ETS2-6525HCL Recombinant Human ETS2 293 Cell Lysate HEK293 Human Non
ETS2-2880M Recombinant Mouse ETS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ETS2-2880M-B Recombinant Mouse ETS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ETS2-4749HF Recombinant Full Length Human ETS2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 469 amino acids

    Involved Pathway

    ETS2 involved in several pathways and played different roles in them. We selected most pathways ETS2 participated on our site, such as Ras signaling pathway,Dorso-ventral axis formation,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway IKBKB,IGF1,GNG8,FGF8,CALML3,KIT,PDGFRB,ANGPT2,RHOA,FGF10
    Dorso-ventral axis formation PIWIL4,PIWIL2,CPEB1,PPP1R2P9,KRAS,CPEB3,SPIRE1,SPIRE2,NOTCH2,SOS1
    HTLV-I infection Il2,POLD4,ANAPC2,ELK4,MAP3K3,CD3E; CD3D,PRKACB,RANBP1,BUB3,GSK3B

    Protein Function

    ETS2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETS2 itself. We selected most functions ETS2 had, and list some proteins which have the same functions with ETS2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FAM188A,GDI2,UBA3,PRKRIR,PEX1,BIRC5,FGFR4,STBD1,GPRASP1,EXOSC5
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NEUROG3,PITX2,IFI203,NFIL3,AEBP2,TCF21,TGIF1,NFIL3-4,SNAI2,TFAP2C
    transcription factor activity, sequence-specific DNA binding FOXN2,MYF6,MNX2B,FOXL2,HLFA,HOXA5,PURBB,NFKB2,ZKSCAN17,POU2F1A
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SOX10,SIX1,KCNA3,MITF,ASCL1,H2AFZ,HOXA10,AEBP2,TCF3A,MAFB
    glucocorticoid receptor binding STAT5B,EP300,YWHAH,NR4A2,NRIP1,FKBP4,STAT3,CEBPB,GRIP1
    DNA binding POLR2A,FOXO3A,POLR3H,EVE1,SOX12,SRY,TRIM33,SOX1B,ZNF287,RBPJ

    Interacting Protein

    ETS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETS2.

    RFWD2;CDK10;TWIST1;TWIST2;RFWD2;ZFYVE9;sSL2;htrA;clpB;q7clb3_yerpe;proA;phnI;ubiG;gcvP;raf1_human_gene

    Resources

    Research Area

    Oncoprotein-Transcription Factors

    References

    • Donnison, M; Broadhurst, R; et al. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. DEVELOPMENTAL BIOLOGY 397:77-88(2015).
    • Kim, JY; Lee, RH; et al. OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1(+), hematopoietic, and endothelial cells from embryonic stem cells. BLOOD 124:2948-2952(2014).

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