ETHE1
-
Official Full Name
ethylmalonic encephalopathy 1 -
Overview
This gene encodes a sulfur dioxygenase that localizes within the mitochondrial matrix. The enzyme functions in sulfide catabolism. Mutations in this gene result in ethylmalonic encephalopathy. -
Synonyms
ETHE1;ethylmalonic encephalopathy 1;protein ETHE1, mitochondrial;HSCO;YF13H12;ethylmalonic encephalopathy protein 1;hepatoma subtracted clone one protein
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- E. coli
- His
- Fc
- GST
- Non
- Flag
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ETHE1 involved in several pathways and played different roles in them. We selected most pathways ETHE1 participated on our site, such as Sulfur metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETHE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sulfur metabolism | PAPSS1,PAPSS2,MPST,SQRDL,IMPAD1,CYCS,CYCSB,PAPSS2B,TST,BPNT1 |
Protein Function
ETHE1 has several biochemical functions, for example, iron ion binding,sulfur dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ETHE1 itself. We selected most functions ETHE1 had, and list some proteins which have the same functions with ETHE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | PHF2,P3H2,P4HA3,CYP26B1,CYP19A1B,C14orf169,FAXDC2,JMJD6,CYP2C50,CYP2C70 |
Interacting Protein
ETHE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETHE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETHE1.
RIF1;ilvD;IGSF21;ATP6V1H;NDUFS7;SIRT4
Resources
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References
- Henriques, BJ; Lucas, TG; et al. Ethylmalonic Encephalopathy ETHE1 R163W/R163Q Mutations Alter Protein Stability and Redox Properties of the Iron Centre. PLOS ONE 9:-(2014).
- Wang, HY; Liu, SS; et al. Identification and characterization of an ETHE1-like sulfur dioxygenase in extremely acidophilic Acidithiobacillus spp.. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 98:7511-7522(2014).
