ETFA
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Official Full Name
electron-transfer-flavoprotein, alpha polypeptide -
Overview
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ETFA;electron-transfer-flavoprotein, alpha polypeptide;electron transfer flavoprotein subunit alpha, mitochondrial;EMA;GA2;glutaric aciduria II;MADD;Alpha ETF;Alpha-ETF;Electron transfer flavoprotein alpha polypeptide;Electron transfer flavoprotein alpha subunit;Electron transfer flavoprotein subunit alpha mitochondrial;Electron transferring flavoprotein alpha polypeptide;ETFA_HUMAN;MS782;electron transfer flavoprotein alpha-subunit;electron transfer flavoprotein, alpha polypeptide
Recombinant Proteins
- Bacillus subtilis
- Mouse
- Rat
- Rhesus macaque
- Chicken
- Human
- Cynomolgus
- Zebrafish
- E. coli or Yeast
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- His&T7
- GST
- Non
- His&Fc&Avi
Involved Pathway
ETFA involved in several pathways and played different roles in them. We selected most pathways ETFA participated on our site, such as Metabolism,Respiratory electron transport,Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., which may be useful for your reference. Also, other proteins which involved in the same pathway with ETFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | C2orf56,ETFB,TIMMDC1,UCP3,LRPPRC,NDUFAF2,NDUFAF6,SCO1,NDUFAF4,TACO1 |
| Metabolism | COX6B1,CKBA,MED22,SLC52A3,SLC6A7,MED8,AGPAT6,COX16,NUBP2,ACER1 |
| Respiratory electron transport | COX14,SURF1,NDUFAF3,ETFDH,C20orf7,NDUFAF6,NDUFAF4,TIMMDC1,SCO1,LRPPRC |
| The citric acid (TCA) cycle and respiratory electron transport | ATP5L,BRP44,FAM36A,ETFB,COX16,SLC25A14,ETFDH,PDK2,NDUFAF4,MPC1 |
Protein Function
ETFA has several biochemical functions, for example, acyl-CoA dehydrogenase activity,electron carrier activity,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETFA itself. We selected most functions ETFA had, and list some proteins which have the same functions with ETFA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| flavin adenine dinucleotide binding | DLDH,ACOXL,ACADL,KDM1A,GFER,ETFDH,GSR,POR,DUS1L,NOS3 |
| oxidoreductase activity | DHDHL,DLDH,GCDHB,Scd1,CYP24A1,TECRL,CYP11C1,CYP2AA4,DHRS13A.2,SDR42E1 |
| fatty-acyl-CoA binding | IVD,ACOX2,ACAD11,ACAD8,ACADSB,ACADL,ECI2,HADHA,PECI,SOAT1 |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACAD9,ACAD8,ACOX2,GCDHB,ACADVL,ACADSB,GCDH,ACOX1,IVD,GCDHA |
| acyl-CoA dehydrogenase activity | GCDHB,ACADL,ACADVL,ACAD8,ACOX2,GCDHA,ACOX1,ACOXL,ACADSB,ACAD9 |
| electron carrier activity | ALDH4A1,AKR7A3,AOC2,GLRX5,HAAO,TXNRD1,ACAD9,ETFB,ETFDH,AIFM1 |
Interacting Protein
ETFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETFA here. Most of them are supplied by our site. Hope this information will be useful for your research of ETFA.
ETFB;EIF1B;MCC;MPG;ELF3;IKBKE;ATG101;DDA1;UBA5;FTSJ1;PRKAB1;TRAF6;CDC42;phnP;ere_dna;MYC;SMS;HNRNPD;ICT1;Tgs1
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References
- Ayoglu, B; Chaouch, A; et al. Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies. EMBO MOLECULAR MEDICINE 6:918-936(2014).
