ESRP1
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Official Full Name
epithelial splicing regulatory protein 1 -
Overview
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. -
Synonyms
ESRP1;epithelial splicing regulatory protein 1;RNA-binding protein 35A;RNA binding motif protein 35A;RNA-binding motif protein 35A;Rbm35a;BC031468;A630065D16;RP23-322G9.1;2210008M09Rik;MGC25805;Esrp1;epithelial splicing regulatory protein 1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Insect Cell
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ESRP1-12559H | Recombinant Human ESRP1, His-tagged | E.coli | Human | His | 27-226a.a. | |
| ESRP1-2153R | Recombinant Rat ESRP1 Protein | Mammalian Cell | Rat | His |
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| ESRP1-5073Z | Recombinant Zebrafish ESRP1 | Mammalian Cell | Zebrafish | His |
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| ESRP1-6538HCL | Recombinant Human ESRP1 293 Cell Lysate | HEK293 | Human | Non |
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| ESRP1-1810R | Recombinant Rat ESRP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ESRP1-1810R-B | Recombinant Rat ESRP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ESRP1-2465H | Recombinant Human ESRP1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Esrp1-2872M | Recombinant Mouse Esrp1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ESRP1-587H | Recombinant Human ESRP1 Protein (Met1-Ile681), His-tagged | Insect Cell | Human | His | Met1-Ile681 |
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Involved Pathway
ESRP1 involved in several pathways and played different roles in them. We selected most pathways ESRP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ESRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ESRP1 has several biochemical functions, for example, mRNA binding,nucleotide binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESRP1 itself. We selected most functions ESRP1 had, and list some proteins which have the same functions with ESRP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | XIAP,ATP6V1H,TRAPPC2,LAIR1,SMAD5,NUSAP1,CSRP3,PRPF31,PIK3CG,BRAF |
| mRNA binding | HSP26,NXF2,MRPS7,RBM25,PIWIL2,RBFOX1,RBM38,RC3H2,RPL13A,XPO5 |
| nucleotide binding | GTF2F2A,ATP2A2B,RALBA,SEPT8B,RBM3,RALBB,CELF5A,MTIF2,MAPK12A,CAMK2G1 |
Interacting Protein
ESRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESRP1.
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References
- Marzese, DM; Liu, M; et al. Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome. PIGMENT CELL & MELANOMA RESEARCH 28:-(2015).
- Ueda, J; Matsuda, Y; et al. Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases. ONCOGENE 33:4485-4495(2014).
