ERRFI1
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Official Full Name
ERBB receptor feedback inhibitor 1 -
Overview
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 (PubMed 7641805)).;It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and;mediates cell signaling (Makkinje et al., 2000 (PubMed 10749885); Fiorentino et al., 2000 (PubMed 11003669)). -
Synonyms
ERRFI1;ERBB receptor feedback inhibitor 1;GENE 33;MIG 6;RALT;mitogen-inducible gene 6 protein;receptor-associated late transducer;MIG6;MIG-6;GENE-33
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ERRFI1-1498R | Recombinant Rhesus monkey ERRFI1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ERRFI1-2145R | Recombinant Rat ERRFI1 Protein | Mammalian Cell | Rat | His |
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| ERRFI1-3491H | Recombinant Human ERRFI1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ERRFI1-5423Z | Recombinant Zebrafish ERRFI1 | Mammalian Cell | Zebrafish | His |
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| ERRFI1-6542HCL | Recombinant Human ERRFI1 293 Cell Lysate | HEK293 | Human | Non |
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| ERRFI1-1323R | Recombinant Rhesus Macaque ERRFI1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ERRFI1-1323R-B | Recombinant Rhesus Macaque ERRFI1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ERRFI1-1802R | Recombinant Rat ERRFI1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ERRFI1-1802R-B | Recombinant Rat ERRFI1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ERRFI1-4607HF | Recombinant Full Length Human ERRFI1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 462 amino acids |
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Involved Pathway
ERRFI1 involved in several pathways and played different roles in them. We selected most pathways ERRFI1 participated on our site, such as EGFR1 Signaling Pathway,Signaling Pathways in Glioblastoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERRFI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | PTPN12,EPPK1,PTK6,ZNF259,MAP3K2,USP6NL,EPS8,KRT17,GRB10,SH2D3C |
Protein Function
ERRFI1 has several biochemical functions, for example, GTPase activator activity,SH3 domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERRFI1 itself. We selected most functions ERRFI1 had, and list some proteins which have the same functions with ERRFI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| small GTPase binding | TSC2,RNF152,RCC2,PEX5,FGD4,FGD2,FGD6,FGD5,FGD1,FGD3 |
| GTPase activator activity | SRGAP2,RAB3GAP1,RABEP2,AXIN2,ARHGAP12,ARHGAP42A,BAI3,RIC8,TBC1D13,SIPA1L1 |
| SH3 domain binding | CTTNBP2,OSTF1,SKAP1,ADAM19,NCKIPSD,SH2D2A,EPS15,ARHGAP6,SH3BGR,ADAM9 |
| protein kinase binding | SMAD3,CDC25B,HCLS1,GHR,XBP1,MAP2K7,TSACC,PIWIL1,CCND1,CD4 |
| protein binding | ADAR,RAPGEF3,CARD10,PIN1,SOCS3,CCDC88A,STAC3,ABCF1,ZC3H15,TLR3 |
Interacting Protein
ERRFI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERRFI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERRFI1.
GRB2;EGFR;SFN;ERBB2
Resources
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References
- Liu, J; Cho, SN; et al. ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis. CELL REPORTS 10:1599-1613(2015).
- Chen, YC; Colvin, ES; et al. Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes. DIABETOLOGIA 57:2066-2075(2014).
