ERCC8

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 8

  • Overview

    This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

  • Synonyms

    ERCC8;excision repair cross-complementing rodent repair deficiency, complementation group 8;CKN1, Cockayne syndrome 1 (classical);DNA excision repair protein ERCC-8;CSA;Cockayne syndrome WD-repeat protein CSA;cockayne syndrome WD repeat protein CSA

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ERCC8-12527H Recombinant Human ERCC8, His-tagged E.coli Human His 1-205a.a.
ERCC8-1509Z Recombinant Zebrafish ERCC8 Mammalian Cell Zebrafish His
ERCC8-26850TH Recombinant Human ERCC8 Wheat Germ Human Non 396 amino acids
ERCC8-3463H Recombinant Human ERCC8 Protein, GST-tagged Wheat Germ Human GST
ERCC8-5291M Recombinant Mouse ERCC8 Protein Mammalian Cell Mouse His
ERCC8-6562HCL Recombinant Human ERCC8 293 Cell Lysate HEK293 Human Non
ERCC8-1436H Recombinant Human ERCC8 Protein, His&GST-tagged E.coli Human His&GST Met1-Gly396
Ercc8-1437M Recombinant Mouse Ercc8 Protein, His&GST-tagged E.coli Mouse His&GST Met1-Gly397
ERCC8-160HF Recombinant Full Length Human ERCC8 Protein In Vitro Cell Free System Human Full L. 396 amino acids
ERCC8-2845M Recombinant Mouse ERCC8 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ERCC8-2845M-B Recombinant Mouse ERCC8 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ERCC8-4563HF Recombinant Full Length Human ERCC8 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 205 amino acids

    Involved Pathway

    ERCC8 involved in several pathways and played different roles in them. We selected most pathways ERCC8 participated on our site, such as DNA Repair,Dual incision in TC-NER,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dual incision in TC-NER TCEA1,ZNF830,ZFP830,KIAA1530,DDB1,PPIE
    Transcription-Coupled Nucleotide Excision Repair (TC-NER) ZFP830,COPS6,PPIE,ZNF830,COPS8,KIAA1530,COPS4,COPS7A,COPS2,COPS3
    DNA Repair CHEK1,COPS7B,INO80C,RAD9A,CLSPN,MGMT,DNA2,TP53BP1,PPIE,KDM4A
    Formation of TC-NER Pre-Incision Complex GPS1,COPS4,COPS2,COPS7B,TCEA1,ZFP830,COPS5,PPIE,COPS7A,COPS8
    Gap-filling DNA repair synthesis and ligation in TC-NER DDB1,PPIE,TCEA1,KIAA1530,ZNF830,ZFP830
    Ubiquitin mediated proteolysis PRPF19,RNF7,UBE2K,ANAPC4,SAE1,FZR1A,RHOBTB1,BTRC,RHOBTB2,SKP1
    Nucleotide Excision Repair POLE2,GTF2H1,COPS7B,NFRKB,XPC,GTF2H2C,POLE4,YY1,COPS4,PPIE

    Protein Function

    ERCC8 has several biochemical functions, for example, NOT DNA helicase activity,NOT DNA-dependent ATPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC8 itself. We selected most functions ERCC8 had, and list some proteins which have the same functions with ERCC8. You can find most of the proteins on our site.

    Function Related Protein
    protein complex binding SLC27A5,ST13,PPP4C,WASF2,RAN,NR0B2,ATF1,KLHL8,SHANK1,MLKL
    NOT DNA helicase activity DNA2,ERCC6
    contributes_to ubiquitin-protein transferase activity KEAP1,KEAP1A,KLHL2,KLHL10,KLHL31,KLHL15,TCEB1B,KBTBD8,UBE2C,KBTBD7
    protein binding TMEM100,SEMA7A,TMX3,PPP1R12C,ELMO3,IKZF2,NAMPT,DYRK4,IRF4,NTSR1

    Interacting Protein

    ERCC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC8.

    XAB2;Ddb1;COPS6;COPS5;UQCRQ;CBR1;CSNK2B;CUL4B

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