ERC1
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Official Full Name
ELKS/RAB6-interacting/CAST family member 1 -
Overview
ERC1, an acronym named for previous protein names ELKS , RAB6IP2 and CAST, is a RIM-binding protein that plays a role in neurotransmitter release and general membrane trafficking in other cell types. Interaction with the GTP-binding protein Rab6 suggests -
Synonyms
ERC1;ELKS/RAB6-interacting/CAST family member 1;RAB6 interacting protein 2 , RAB6IP2;CAST2;ELKS;KIAA1081;MGC12974;RAB6 interacting protein 2;Rab6-interacting protein 2;RAB6IP2;FLJ31750
Recombinant Proteins
- Human
- Rat
- Mouse
- S.cerevisiae
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
ERC1 involved in several pathways and played different roles in them. We selected most pathways ERC1 participated on our site, such as NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | CD40LG,TRAF3,NFKB2,TNFSF14,CCL21B,TRAF2,LTBR,LAT,ZAP70,CXCL2 |
Protein Function
ERC1 has several biochemical functions, for example, PDZ domain binding,Rab GTPase binding,leucine zipper domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERC1 itself. We selected most functions ERC1 had, and list some proteins which have the same functions with ERC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LIMK1,PICK1,EIF1AD,EPM2AIP1,GATA5,CASP9,ZNF580,Siglec1,PARD6B,BNIPL |
| leucine zipper domain binding | NRL,ATF4,DDIT3,AATF,PMF1,CRX,MKL1,DAPK3,KCNA3,PAWR |
| PDZ domain binding | SSTR2,GRIA1,PDZK1,ATP2B1,GRASP,DTNA,LNX1,GNG12,SLC26A6,KIDINS220B |
| Rab GTPase binding | RGP1,MYRIP,SLC6A4,ANXA2,EVI5L,LLGL2,AP3M1,RAB3GAP1,RAB8A,SYTL3 |
Interacting Protein
ERC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERC1.
YWHAG;PARP2;NR4A1;PHB;SMAD2;TWF2;KBTBD7;Ckap5;a0jp85;DVL2;SLC16A6;MYC;MAPK4;Kif4;Actb;KIF23;STK4;MAPRE1;CEP135
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References
- Huijbers, MG; Lipka, AF; et al. Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. HUMAN IMMUNOLOGY 74:849-851(2013).
- Billings, SE; Clarke, GL; et al. ELKS1 and Ca2+ channel subunit beta 4 interact and colocalize at cerebellar synapses. NEUROREPORT 23:49-54(2012).
