ERBB2IP
-
Official Full Name
erbb2 interacting protein -
Overview
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. -
Synonyms
ERBB2IP;erbb2 interacting protein;protein LAP2;densin 180 like protein;ERBIN;LAP2;densin-180-like protein;ERBB2-interacting protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ERBB2IP-779H | Recombinant Human ERBB2IP protein, His-tagged | E.coli | Human | His | 461-810 aa | |
| ERBB2IP-7791Z | Recombinant Zebrafish ERBB2IP | Mammalian Cell | Zebrafish | His |
|
Involved Pathway
ERBB2IP involved in several pathways and played different roles in them. We selected most pathways ERBB2IP participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB2IP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | IL1B,CARD18,CARD9,PSTPIP1B,CARD8,CASPA,NAIP1,MAPK8A,CCL5,IL6 |
Protein Function
ERBB2IP has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB2IP itself. We selected most functions ERBB2IP had, and list some proteins which have the same functions with ERBB2IP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ERBB2IP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB2IP here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB2IP.
Resources
Related Services
Related Products
References
- Zanetti, M; et al. Tapping CD4 T Cells for Cancer Immunotherapy: The Choice of Personalized Genomics. JOURNAL OF IMMUNOLOGY 194:2049-2056(2015).
- Miamen, AG; Gustafson, MP; et al. Rethinking Cancer Immunotherapy: Using Advanced Cancer Genetics in Immune-Mediated Eradication of Gastrointestinal Cancers. HEPATOLOGY 60:2121-2124(2014).
