EPM2A
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Official Full Name
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) -
Overview
This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. -
Synonyms
EPM2A;epilepsy, progressive myoclonus type 2A, Lafora disease (laforin);epilepsy, progressive myoclonus type 2, Lafora disease (laforin);laforin;LD;LDE;LAFPTPase;lafora PTPase;EPM2;MELF
Recombinant Proteins
- Chicken
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EPM2A-2748C | Recombinant Chicken EPM2A | Mammalian Cell | Chicken | His |
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| EPM2A-3411H | Recombinant Human EPM2A Protein, GST-tagged | Wheat Germ | Human | GST |
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| EPM2A-5255M | Recombinant Mouse EPM2A Protein | Mammalian Cell | Mouse | His |
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| EPM2A-568HCL | Recombinant Human EPM2A cell lysate | Human | Non |
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| EPM2A-2821M | Recombinant Mouse EPM2A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EPM2A-2821M-B | Recombinant Mouse EPM2A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EPM2A-4388HF | Recombinant Full Length Human EPM2A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 331 amino acids |
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Involved Pathway
EPM2A involved in several pathways and played different roles in them. We selected most pathways EPM2A participated on our site, such as Disease,Diseases of carbohydrate metabolism,Diseases of metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases of metabolism | SFTPB,CYP11A1,SFTPC,GYG2,FDX1L,FDXR,FDX1,MTRR,GYG1,CCDC59 |
| Glucose metabolism | SLC25A1A,GYG1,GYG1B,GYG2,SLC25A10,AGL,SLC25A13,SLC25A12,GYG1A,PYGMB |
| Glycogen synthesis | GYG1B,NHLRC1,GYG1A |
| Metabolism of carbohydrates | SLC25A10,ST3GAL3A,CHP,SLC5A4,HS3ST4,SLC25A13,B3GNT2A,B3GAT2,Gpc2,HAS1 |
| Diseases of carbohydrate metabolism | GYG1,GYG2 |
| Metabolism | NDUFAF4,ETFB,PPM1K,PDK4,HS3ST6,APOBB.1,SULT2ST2,GC,COX4I1,CYP2K18 |
| Disease | PDCD6IP,MTRR,NMT2,JAG2,FGFR1OP,KREMEN1,JAG1,MYO18A,OPN1SW,ELL |
Protein Function
EPM2A has several biochemical functions, for example, carbohydrate phosphatase activity,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPM2A itself. We selected most functions EPM2A had, and list some proteins which have the same functions with EPM2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TBX6,TRIM39,RAD9B,C19orf47,PDE6D,ZFP488,PPEF1,RHOT1,KCNA2,MGAT5B |
| protein serine/threonine phosphatase activity | DUSP23B,PDP2,PPM1DB,PPP3CA,CTDNEP1A,UBLCP1,PPM1K,PPEF2,PP2D1,PPM1E |
| starch binding | STBD1,GPCPD1 |
| protein tyrosine/serine/threonine phosphatase activity | PTENB,DUSP26,DUSP13A,SSH2B,CDC14A,DUPD1,DUSP22,SACM1L,DUSP19B,SSH2 |
| protein tyrosine phosphatase activity | MTM1,MTMR1,PTPRR,KIAA1274,PTPN11,PTPN22,DUPD1,DUSP28,MTMR1B,DUSP3 |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | INPP5E,SYNJ2,INPP5B,PTPMT1,OCRL |
Interacting Protein
EPM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of EPM2A.
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