EPC1
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Official Full Name
enhancer of polycomb homolog 1 (Drosophila) -
Overview
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] -
Synonyms
EPC1;enhancer of polycomb homolog 1 (Drosophila);Epl1;enhancer of polycomb homolog 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EPC1-3364H | Recombinant Human EPC1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EPC1-5235M | Recombinant Mouse EPC1 Protein | Mammalian Cell | Mouse | His |
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| EPC1-566HCL | Recombinant Human EPC1 cell lysate | Human | Non |
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| EPC1-2811M | Recombinant Mouse EPC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EPC1-2811M-B | Recombinant Mouse EPC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EPC1-4278HF | Recombinant Full Length Human EPC1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 813 amino acids |
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Involved Pathway
EPC1 involved in several pathways and played different roles in them. We selected most pathways EPC1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | ATXN7L3,ZZZ3,TADA1,ELP3,TADA3,PAX3A,PBRM1L,KDM3B,KANSL2,BRPF1 |
| HATs acetylate histones | VPS72,MSL1A,ATXN7,ING5,DMAP1,USP22,PHF15,KAT7A,ELP2,KAT6B |
| Chromatin organization | SUDS3,ATXN7L3,SMARCD3,SAP30,C3orf75,ARID5B,KAT7A,ANO9A,SAP130,SMARCD1 |
Protein Function
EPC1 has several biochemical functions, for example, contributes_to histone acetyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPC1 itself. We selected most functions EPC1 had, and list some proteins which have the same functions with EPC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | UPP2,KRT2,PKN1,RPL15,COPS5,CTBP1,ATE1,CRHR1,UBE2N,KLF15 |
| contributes_to histone acetyltransferase activity | SUPT3H,TAF9,SUPT7L,TADA3,TEX30,TAF5L,TADA1,KAT5,KAT2A,TAF6L |
Interacting Protein
EPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPC1.
RINT1;KRT15;MRGBP;ACTL6A;MYC;VPS72;RUVBL2;RUVBL1
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References
- Che, CL; Zhang, LJ; et al. RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:361-367(2015).
- Lehman, HL; Yang, XB; et al. p120-Catenin Down-Regulation and Epidermal Growth Factor Receptor Overexpression Results in a Transformed Epithelium That Mimics Esophageal Squamous Cell Carcinoma. AMERICAN JOURNAL OF PATHOLOGY 185:240-251(2015).
