EML1

  • Official Full Name

    echinoderm microtubule associated protein like 1

  • Overview

    Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    EML1;echinoderm microtubule associated protein like 1;EMAPL;echinoderm microtubule-associated protein-like 1;ELP79;EMAP;HuEMAP;EMAL1_HUMAN;EMAP-1;FLJ45033;HuEMAP-1

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Zebrafish
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EML1-2092R Recombinant Rat EML1 Protein Mammalian Cell Rat His
EML1-28291TH Recombinant Human EML1 Wheat Germ Human Non 815 amino acids
EML1-3281H Recombinant Human EML1 Protein, GST-tagged Wheat Germ Human GST
EML1-5179M Recombinant Mouse EML1 Protein Mammalian Cell Mouse His
EML1-7792Z Recombinant Zebrafish EML1 Mammalian Cell Zebrafish His
EML1-6609HCL Recombinant Human EML1 293 Cell Lysate HEK293 Human Non
EML1-148HF Recombinant Full Length Human EML1 Protein In Vitro Cell Free System Human Full L. 815 amino acids
EML1-1749R Recombinant Rat EML1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
EML1-1749R-B Recombinant Rat EML1 Protein Pre-coupled Magnetic Beads HEK293 Rat
EML1-2774M Recombinant Mouse EML1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EML1-2774M-B Recombinant Mouse EML1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EML1-4244HF Recombinant Full Length Human EML1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 815 amino acids

    Involved Pathway

    EML1 involved in several pathways and played different roles in them. We selected most pathways EML1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EML1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    EML1 has several biochemical functions, for example, calcium ion binding,microtubule binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EML1 itself. We selected most functions EML1 had, and list some proteins which have the same functions with EML1. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding GABARAPA,FES,SNCA,NEIL2,DPYSL5,PEX14,KRIT1,MAP4,CCDC87,KIF3CB
    tubulin binding AGBL5,KIF14,STMN2B,ATF5,RITA1,MAP1S,RABGAP1,PRNP,STMN4L,TBCA
    protein binding PAX5,ICK,PDZD7,TRA2B,ODC1,HAX1,CDKN2A,ZUFSP,MCM3,RIT1
    calcium ion binding PCDH1G3,MEX3B,SYT11,F7I,TMEM8C,ANXA3B,CALB2A,EFHD2,S100B,SYT5B

    Interacting Protein

    EML1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EML1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EML1.

    ISG20L2;NUDC

    Resources

    References

    • Kielar, M; Tuy, FPD; et al. Mutations in the gene EML1 / EMl1, neuronal progenitors and heterotopias in humans and mice. M S-MEDECINE SCIENCES 30:1087-1090(2014).
    • Cocas, L; Pleasure, SJ; et al. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. NATURE NEUROSCIENCE 17:894-895(2014).

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