EME1

  • Official Full Name

    essential meiotic endonuclease 1 homolog 1 (S. pombe)

  • Overview

    This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.

  • Synonyms

    EME1;essential meiotic endonuclease 1 homolog 1 (S. pombe);crossover junction endonuclease EME1;FLJ31364;MMS4L;SLX2 structure specific endonuclease subunit homolog A (S. cerevisiae);SLX2A;6820428D13;EC 3.1.22.-;Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe);EME1, S. pombe, homolog of, 1;essential meiotic endonuclease 1 homolog 1 (S pombe);Essential Meiotic Endonuclease 1 Homolog 1;essential meiotic endonuclease 1 homolog 2;Essential meiotic endonuclease 1, S. pombe, homolog of, 1;hMMS4;homolog of yeast EME1 endonuclease;MGC106543;MMS4;MMS4 homolog;OTTHUMP00000221188;OTTHUMP00000221189;OTTHUMP00000221193;SLX2 structure-specific endonuclease subunit homolog A

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&SUMO
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EME1-12431H Recombinant Human EME1, GST-tagged E.coli Human GST C-term-350a.a.
EME1-3275H Recombinant Human EME1 Protein, GST-tagged Wheat Germ Human GST
EME1-5171M Recombinant Mouse EME1 Protein Mammalian Cell Mouse His
EME1-552HCL Recombinant Human EME1 cell lysate Human Non
EME1-1106H Recombinant Human EME1 Protein (1-583 aa), His-SUMO-tagged E.coli Human His&SUMO 1-583 aa
EME1-2768M Recombinant Mouse EME1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EME1-2768M-B Recombinant Mouse EME1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EME1-4234HF Recombinant Full Length Human EME1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 583 amino acids

    Involved Pathway

    EME1 involved in several pathways and played different roles in them. We selected most pathways EME1 participated on our site, such as DNA Double-Strand Break Repair,DNA Repair,Fanconi Anemia Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HDR through Homologous Recombination (HRR) FUZ,EME2,GEN1,KIAA0146,RAD51AP1,RBBP8,WRN,RHNO1,RAD9,HUS1
    Fanconi Anemia Pathway FANCG,EME2,FANCD2,PMS2,USP1,MUS81,RMI1,FANCB,ERCC1,REV3L
    DNA Repair MCRS1,APITD1,RAD17,TDP1,USP43A,USP43,ASCC3,ASCC1,COPS6,SMARCA5
    Homologous recombination XRCC2,POLD4,SSBP1,BRCA2,RAD51L3,RAD54B,POLD1,RAD52,SHFM1,RPA3
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) RNF168,TIPIN,PPP4R2,EME2,BRCC3,TP53BP1,RTEL1,PPP4CA,RAD1,RHNO1
    DNA Double-Strand Break Repair TIPIN,BABAM1,BRCC3,UIMC1,EYA2,KDM4B,DNA2,EME2,FAM175A,SMARCA5
    Homology Directed Repair KIAA0146,EME2,PPP4R2B,RNF4,PPP4R2A,TIMELESS,TIPIN,FUZ,PPP4CA,PPP4CB

    Protein Function

    EME1 has several biochemical functions, for example, DNA binding,endonuclease activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EME1 itself. We selected most functions EME1 had, and list some proteins which have the same functions with EME1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZFP41,NTNG1,ZNF789,CARF,ZNF670,ZNF7,ALS2CR8,BANF2,SNAPC3,ZNF692
    metal ion binding OAS3,HECTD1,PRDM1,GALNT5,BMX,ZNF395B,ADPRHL2,ADAM1B,MUT,INPP5B
    endonuclease activity RNASE7,EXOG,ANG,CL2,ANG3,RSFR,DCLRE1C,DIS3,PELO,ZC3H12A
    protein binding SLC11A2,RAB25,FAM54B,TXNRD3,C9orf43,PTGIS,CRY1,CALML3,PHLDA1,KAT5

    Interacting Protein

    EME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EME1.

    MUS81;SLX4;y-structure-oligo-1;DDB1;Srp72;Nek2;Shoc2;YEATS4;vpr;USF1;PML;FEN1

    Resources

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