EIF4EBP3
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Official Full Name
eukaryotic translation initiation factor 4E binding protein 3 -
Overview
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. -
Synonyms
EIF4EBP3;eukaryotic translation initiation factor 4E binding protein 3;eukaryotic translation initiation factor 4E-binding protein 3;4E BP3;eIF4E binding protein 3;Eukaryotic initiation factor 4E binding protein 3;OTTHUMP00000159879;eIF4E-binding protein 3;eukaryotic initiation factor 4E-binding protein 3;4EBP3;4E-BP3
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
EIF4EBP3 involved in several pathways and played different roles in them. We selected most pathways EIF4EBP3 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4EBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | POP5,PABPC5,GEMIN4,UPF3A,EEF1A1A,CASC3,RPP40,GEMIN2,EIF1B,RPP25 |
Protein Function
EIF4EBP3 has several biochemical functions, for example, eukaryotic initiation factor 4E binding,protein binding,translation repressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4EBP3 itself. We selected most functions EIF4EBP3 had, and list some proteins which have the same functions with EIF4EBP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRA2B,ALKBH8,FASN,MXD4,DLG1,PPP4R4,LARP4B,POU3F2,TEX19.1,UBE2Q1 |
| translation repressor activity | PAIP2,SAMD4,PATL2,CIRBP,IREB2,EIF4EBP2,EIF4EBP1,TRIM71,SAMD4A |
| eukaryotic initiation factor 4E binding | LARP1,HHEX,OTX2,EIF4EBP1,EIF4EBP3L,ANGEL1,EIF4G1,DDX3X,GRA,EIF4EBP2 |
Interacting Protein
EIF4EBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4EBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4EBP3.
EIF4E;RPA2;Eif4e2;EIF4E2;Smad6
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References
- Wang, ZS; Ma, XH; et al. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 94:1243-1253(2012).
- Rojo, F; Najera, L; et al. 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. CLINICAL CANCER RESEARCH 13:81-89(2007).
