EIF3B

  • Official Full Name

    eukaryotic translation initiation factor 3, subunit B

  • Overview

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

  • Synonyms

    EIF3B;eukaryotic translation initiation factor 3, subunit B;PRT1;EIF3S9;EIF3-ETA;EIF3-P110;EIF3-P116;eukaryotic translation initiation factor 3 subunit B;hPrt1;eIF-3-eta;eIF3 p110;eIF3 p116;prt1 homolog;eukaryotic translation initiation factor 3 subunit 9;eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa;eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Mammalian cells
  • His
  • Myc&DDK
  • His&Fc&Avi
  • Flag

    Involved Pathway

    EIF3B involved in several pathways and played different roles in them. We selected most pathways EIF3B participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport EIF5B,NUP98,CASC3,ALYREF,RANBP2,SRRM1,EIF2S1B,PABPC4,EIF1B,TRNT1

    Protein Function

    EIF3B has several biochemical functions, for example, RNA binding,nucleic acid binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF3B itself. We selected most functions EIF3B had, and list some proteins which have the same functions with EIF3B. You can find most of the proteins on our site.

    Function Related Protein
    translation initiation factor activity EIF3HA,EIF3JB,EIF1AY,EIF5,EIF3J,EIF4E2RS1,EIF4BB,EIF1AXB,EIF1AXA,EIF3BA
    contributes_to translation initiation factor activity EIF3EB,EIF2B3,EIF2B1,EIF3K,EIF3I,EIF3J,EIF2B2,EIF3HB,EIF3EA,EIF2B4
    nucleotide binding VMHCL,PRKG1A,IGF1RB,DHX37,RAD51L1,HNRNPA1L2,SF3B4,SETD1BA,CPEB2,SREK1
    nucleic acid binding DHX37,ZFP143,ZFP354C,EAR2,YY1B,ZFP110,EHD4,SP3A,GPATCH1,GLIS2
    RNA binding SYNCRIP,SRSF12,EIF5A,SRP9,CNOT6,RPL6,NSUN5B,A1CF,IMPDH2,D19BWG1357E
    protein binding BTG3,CHDH,MRPS16,APOH,CADM1,ATP1A1,EXOC8,IK,EED,PFTK1
    translation initiation factor binding POLR2G,DDX3X,POLR2D,TBL2,LIN28A,ZFP259,EIF2B5,CELF1,POLR2GL,EIF2B4

    Interacting Protein

    EIF3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF3B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF3B.

    Eif3a;Eif4a1;Rps6;Eif4e;Eif4g1;Rps6kb1;Eif3i;Ywhae

    Resources

    References

    • Aylett, CHS; Boehringer, D; et al. Structure of a Yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex. NATURE STRUCTURAL & MOLECULAR BIOLOGY 22:269-271(2015).
    • Rezende, AM; Assis, LA; et al. The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates - identification of conserved and divergent features based on orthologue analysis. BMC GENOMICS 15:-(2014).

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