EIF2B2
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Official Full Name
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -
Overview
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. -
Synonyms
EIF2B2;eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa;eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD);translation initiation factor eIF-2B subunit beta;EIF 2Bbeta;EIF2B;S20I15;S20III15;eIF-2B GDP-GTP exchang
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- T7
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
EIF2B2 involved in several pathways and played different roles in them. We selected most pathways EIF2B2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF4EBP3L,RNPS1,RAE1,ALYREF,NUP214,EIF3D,NUP133,EIF5,RBM8A,FXR2 |
Protein Function
EIF2B2 has several biochemical functions, for example, ATP binding,GTP binding,NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B2 itself. We selected most functions EIF2B2 had, and list some proteins which have the same functions with EIF2B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DHX9,ACSS2,PIP4K2A,DDX21,MAPK1,KHK,NARS2,NADK2,HUNK,SIK2 |
| contributes_to guanyl-nucleotide exchange factor activity | EIF2B4,EIF2B3,LAMTOR1,EIF2B5,LAMTOR2,EIF2B1,C7orf59,ALS2,LAMTOR3,HBXIP |
| NOT S-methyl-5-thioribose-1-phosphate isomerase activity | EIF2B4,EIF2B3,EIF2B1 |
| GTP binding | GUCY1A3,RALAA,TUBG1,RP2,NPR2,SEPT5,GNAO1,GTPBP1L,GFM2,RAC2 |
| contributes_to translation initiation factor activity | EIF3S6IP,EIF3E,EIF3S10,EIF3H,EIF3B,EIF3M,EIF3D,EIF2B3,EIF3A,EIF3G |
| protein binding | ZNF703,ZKSCAN5,AQP5,CBX3,SYNDIG1,NIPSNAP3A,HOXA9,SRGAP2,ABCE1,AXL |
Interacting Protein
EIF2B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B2.
CSNK2A2;CCT3;C9orf72;pi3p;Srp72;NSS;RPL10;DCC;EPB41L3
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References
- Unal, O; Ozgen, B; et al. Vanishing White Matter With Hepatomegaly and Hypertriglyceridemia Attacks. JOURNAL OF CHILD NEUROLOGY 28:1509-1512(2013).
- Hata, Y; Kinoshita, K; et al. An autopsy case of infantile-onset vanishing white matter disease related to an EIF2B2 mutation (V85E) in a hemizygous region. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:3355-3362(2014).
