EGR3
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Official Full Name
early growth response 3 -
Overview
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010] -
Synonyms
EGR3;early growth response 3;EGR-3;PILOT;early growth response protein 3;zinc finger protein pilot
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
- His&T7
- His&Fc&Avi
Involved Pathway
EGR3 involved in several pathways and played different roles in them. We selected most pathways EGR3 participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Hepatitis B,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis B | APAF1,FASLG,IKBKE,PTEN,TIRAP,TRP53,TBK1,IFNA5,Casp3,MAP2K2 |
| Viral carcinogenesis | EIF2AK2,HDAC2,CCND1,TP53,HIST1H4M,DLG1,GTF2H3,RBL2,UBR4,UBE3A |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | CTLA4,IKZF1,CSF2,EGR1,DGKA,POU2F1,IRF4,JUNB,EGR4,EGR2 |
Protein Function
EGR3 has several biochemical functions, for example, DNA binding,metal ion binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR3 itself. We selected most functions EGR3 had, and list some proteins which have the same functions with EGR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF684,BANF1,RFX2,SIX6,ZBTB41,POU2F1B,ZSCAN4C,ZNF771,HIST1H2BP,C5orf20 |
| transcription factor activity, sequence-specific DNA binding | RORAB,ZNF445,HLF,WT1B,TRIM22,ESR2A,KCNA3,ALX1,NFIX,SS18L1 |
| metal ion binding | BCMO1,PVALB6,NPAS2,SDHDA,TRAF4B,OAS1,PLEKHM1,NUDT17,ZBTB16A,GUCA1G |
Interacting Protein
EGR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR3.
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References
- Shin, H; Kwon, S; et al. The Transcription Factor Egr3 Is a Putative Component of the Microtubule Organizing Center in Mouse Oocytes. PLOS ONE 9:-(2014).
- Darmanis, S; Cui, T; et al. Identification of Candidate Serum Proteins for Classifying Well-Differentiated Small Intestinal Neuroendocrine Tumors. PLOS ONE 8:-(2013).
