EGLN2
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Official Full Name
egl-9 family hypoxia-inducible factor 2 -
Overview
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011] -
Synonyms
EGLN2;egl-9 family hypoxia-inducible factor 2;EIT6;PHD1;HPH-1;HPH-3;HIFPH1;HIF-PH1;egl nine homolog 2;estrogen-induced tag 6;HIF-prolyl hydroxylase 1;hypoxia-inducible factor prolyl hydroxylase 1;prolyl hydroxylase domain-containing protein 1
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
EGLN2 involved in several pathways and played different roles in them. We selected most pathways EGLN2 participated on our site, such as Cellular response to hypoxia,Cellular responses to stress,HIF-1 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | VHL,PIK3R3,MAPK1,MAP2K2,KRAS,ETS1,RAP1B,ARAF,CUL2,AKT2 |
| HIF-2-alpha transcription factor network | CITED2,EGLN3,HIF1AN |
| Regulation of Hypoxia-inducible Factor (HIF) by oxygen | HIF1AN,EPAS1B,HIF3A,EGLN1B,HIF1AL,EGLN3 |
| HIF-1 signaling pathway | EGLN3,CYBB,AHA-1 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | HIF1AL,EGLN1B,EGLN3,HIF3A,EPAS1B |
| Cellular response to hypoxia | EPAS1B,EGLN3,HIF1AN,HIF3A,HIF1AL,EGLN1B |
| Pathways in cancer | SUFU,VHL,NCOA4,AHA-1,LAMA4,NFKB1,ARNT,AXIN2,APC,Pdgfa&Pdgfb |
| Cellular responses to stress | UBN1,AMBRA1,KIAA1967,RING1,HBXIP,HIF1AL,HMGA1,BAG3,CBX8,KAT5 |
Protein Function
EGLN2 has several biochemical functions, for example, L-ascorbic acid binding,ferrous iron binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN2 itself. We selected most functions EGLN2 had, and list some proteins which have the same functions with EGLN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-ascorbic acid binding | LEPREL1,OGFOD3,P4HA3,P3H2,PLOD1,PAM,P4HA1A,LEPRE1,PLOD3,P4HA1 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | KDM5B,P4HTM,ALKBH4,KDM5D,KDM5A,C14orf169,JHDM1D,ALKBH5,ALKBH8,EGLN1 |
| protein binding | POP1,AP2A2,PLK4,STOX1,PIP,PSMD14,POP4,NETO2,TTPA,ADAM22 |
| peptidyl-proline 4-dioxygenase activity | EGLN1,EGLN3 |
| ferrous iron binding | FTO,BCO1,CDO1,Trf,ISCA2,SERPINB1A,ALKBH3,TET2,FECH,FXN |
| oxygen sensor activity | NOX4,HIF1AN |
Interacting Protein
EGLN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN2.
HIF1A;SRPK2;EPAS1;VHL;FAM46A;MOB4
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