EFHC1
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Official Full Name
EF-hand domain (C-terminal) containing 1 -
Overview
EFHC1 gene encodes a protein with an EF-hand motif; EFHC1 protein affects programmed cell death through effects on calcium influx; overexpression of EFHC1 in hippocampal primary culture neurons induces apoptosis. EFHC1 is widely expressed. -
Synonyms
EFHC1;EF-hand domain (C-terminal) containing 1;mRib72-1;myoclonin1;1700029F22Rik;EF-hand domain-containing protein 1;myoclonin-1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
EFHC1 involved in several pathways and played different roles in them. We selected most pathways EFHC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EFHC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
EFHC1 has several biochemical functions, for example, calcium ion binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFHC1 itself. We selected most functions EFHC1 had, and list some proteins which have the same functions with EFHC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPINK1,BMPR1AA,SCRIB,TNFRSF10B,MUL1,ARL3,PHAX,ANXA10,UVRAG,QARS |
| calcium ion binding | CALB2,ACTN3,MMP13A,CALML5,PLCD1A,DLB,DNER,SCGN,Shh,NID2 |
| protein C-terminus binding | SP1,PHB2,NCL,CTBP1,SNF8,CD2AP,CACNA1B,PIAS4,TOP2A,NEIL1 |
Interacting Protein
EFHC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFHC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFHC1.
TCF4;REL;EIF4ENIF1;IKZF3
Resources
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References
- Subaran, RL; Conte, JM; et al. Pathogenic EFHC1 mutations are tolerated in healthy individuals dependent on reported ancestry. EPILEPSIA 56:188-194(2015).
- Pal, D; Helbig, I; et al. COMMENTARY: PATHOGENIC EFHC1 MUTATIONS ARE TOLERATED IN HEALTHY INDIVIDUALS DEPENDENTONREPORTED ANCESTRY. EPILEPSIA 56:195-196(2015).
