EDEM2
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Official Full Name
ER degradation enhancer, mannosidase alpha-like 2 -
Overview
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the;proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in;ERAD of glycoproteins (Mast et al., 2005 (PubMed 15537790)). -
Synonyms
EDEM2;ER degradation enhancer, mannosidase alpha-like 2;C20orf31, C20orf49, chromosome 20 open reading frame 31;ER degradation-enhancing alpha-mannosidase-like 2;bA4204.1;FLJ10783;C20orf49;EDEM 2;EDEM2_HUMAN;ER degradation enhancer mannosidase alpha like 2;ER degradation enhancing alpha mannosidase like 2;ER degradation enhancing mannosidase like protein 2;OTTHUMP00000030728;ER degradation-enhancing-mannosidase-like protein 2;C20orf31
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cell
- Human Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EDEM2-1377R | Recombinant Rhesus monkey EDEM2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| EDEM2-196H | Recombinant Human EDEM2, His tagged | Human Cell | Human | His | 1-492 a.a. |
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| EDEM2-3051H | Recombinant Human EDEM2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EDEM2-862HCL | Recombinant Human EDEM2 cell lysate | Human Cell | Human | Non |
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| EDEM2-1202R | Recombinant Rhesus Macaque EDEM2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| EDEM2-1202R-B | Recombinant Rhesus Macaque EDEM2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| EDEM2-4185HF | Recombinant Full Length Human EDEM2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 578 amino acids |
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Involved Pathway
EDEM2 involved in several pathways and played different roles in them. We selected most pathways EDEM2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDEM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | HSPA1B,SSR1,RPN2,CAPN2B,UBE2D2L,CRYAA,PKZ,DNAJB1A,CAPN2A,BAG1 |
Protein Function
EDEM2 has several biochemical functions, for example, calcium ion binding,glycoprotein binding,NOT mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDEM2 itself. We selected most functions EDEM2 had, and list some proteins which have the same functions with EDEM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | MAN1A,MAN1B1,MAN1C1,MAN1A2,MAN1A1,EDEM1 |
| calcium ion binding | SYT12,GSN,MYL5,SNED1,SYTL1,NELL1,PCDH1G11,CALM4,CDH16,LTBP3 |
| glycoprotein binding | HFE2,ERBB2,CDH1,ERLEC1,FBXO2,FBXO6,FLNA,RGMA,SERPINA1A,SERPINA1 |
Interacting Protein
EDEM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDEM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDEM2.
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