ECE2
-
Official Full Name
endothelin converting enzyme 2 -
Overview
Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that generate functionally;pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001 (PubMed 11718899)). -
Synonyms
ECE2;endothelin converting enzyme 2;endothelin-converting enzyme 2;KIAA0604;MGC2408;MGC78487;ECE 2;ECE-2;ECE2_HUMAN;Endothelin-converting enzyme 2 region;Hypothetical protein MGC2408;MGC17664
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian cells
- Wheat Germ
- Human Cell
- In Vitro Cell Free System
- His
- Fc
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ECE2-12265H | Recombinant Human ECE2, His-tagged | E.coli | Human | His | 1-255a.a. | |
| ECE2-690H | Recombinant Human ECE2 protein(Gly199-Trp883), hFc-tagged | HEK293 | Human | Fc | 199-883 a.a. | |
| ECE2-1877H | Recombinant Human ECE2 protein, GST-tagged | E.coli | Human | GST | 1-255 aa | |
| Ece2-222M | Recombinant Mouse Ece2 Protein, His-tagged | E.coli | Mouse | His | Met1~Phe163 | |
| ECE2-529H |
Active Recombinant Human ECE2, His&Val-tagged
|
Mammalian cells | Human | His | 104-787 a.a. |
|
| ECE2-3028H | Recombinant Human ECE2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| ECE2-3813H | Recombinant Human ECE2, His tagged | HEK293 | Human | His | Gly 199-Trp 883 |
|
| ECE2-2052HCL | Recombinant Human ECE2 cell lysate | Human Cell | Human | Non |
|
|
| ECE2-2976HCL | Recombinant Human ECE2 cell lysate | Human Cell | Human | Non |
|
|
| ECE2-4152HF | Recombinant Full Length Human ECE2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 255 amino acids |
|
| ECE2-4351H | Recombinant Human ECE2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| ECE2-4351H-B | Recombinant Human ECE2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
Involved Pathway
ECE2 involved in several pathways and played different roles in them. We selected most pathways ECE2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ECE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ECE2 has several biochemical functions, for example, metal ion binding,metalloendopeptidase activity,methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECE2 itself. We selected most functions ECE2 had, and list some proteins which have the same functions with ECE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FOXN3,FGF2,EXOC3L,TMEM185A,CRCP,CIZ1,EXOSC3,PPP2R1A,CASP10,IRF8 |
| metalloendopeptidase activity | ADAMTS2,PHEX,BMP1B,YBEY,TLL1,NPSN,ADAM20,MEP1A,ADAMTS8,TLL2 |
| metal ion binding | CYP46A1.2,RNF216,ARMC1L,ADCY3,SOBPB,OSGEPL1,KCNH7,PHLPP1,CHPF,COL5A1 |
| methyltransferase activity | PRMT5,METTL21A,ALDH1L2,EHMT1A,PRDM5,SETD1BA,METTL8,EHMT1,METTL10,SETD1B |
Interacting Protein
ECE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECE2.
SYNE4;NDUFS1;CD86;CASP10
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References
- Mouthon, L; Bussone, G; et al. Scleroderma Renal Crisis. JOURNAL OF RHEUMATOLOGY 41:1040-1048(2014).
- Maguire, JJ; Davenport, AP; et al. Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. BRITISH JOURNAL OF PHARMACOLOGY 171:5555-5572(2014).
