E2F5
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Official Full Name
E2F transcription factor 5, p130-binding -
Overview
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. -
Synonyms
E2F5;E2F transcription factor 5, p130-binding;transcription factor E2F5;E2F 5;E2F transcription factor 5;E2F transcription factor 5 p130 binding;p130 binding;OTTHUMP00000227505;OTTHUMP00000227506;OTTHUMP00000227507;OTTHUMP00000227508;E2F-5
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| E2F5-007H | Recombinant Human E2F5 Protein, His-tagged | E.coli | Human | His |
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| E2F5-11651Z | Recombinant Zebrafish E2F5 | Mammalian Cell | Zebrafish | His |
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| E2F5-2631C | Recombinant Chicken E2F5 | Mammalian Cell | Chicken | His |
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| E2F5-3009H | Recombinant Human E2F5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| E2F5-4934M | Recombinant Mouse E2F5 Protein | Mammalian Cell | Mouse | His |
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| E2F5-7826Z | Recombinant Zebrafish E2F5 | Mammalian Cell | Zebrafish | His |
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| E2F5-2598M | Recombinant Mouse E2F5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| E2F5-2598M-B | Recombinant Mouse E2F5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| E2f5-2708M | Recombinant Mouse E2f5 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| E2F5-4114HF | Recombinant Full Length Human E2F5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 346 amino acids |
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| E2F5-935H | Recombinant Human E2F5 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
E2F5 involved in several pathways and played different roles in them. We selected most pathways E2F5 participated on our site, such as Cell cycle,TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CDC26,CEP164,DCTN3,NIPBLA,NIPBLB,TMEM188,NCAPD3,PKMYT1,CDKN2B,CCNH |
| TGF-beta signaling pathway | CHRD,SKP1,SMAD4,ACVR2A,BMPR1B,BMPR1A,BAMBIB,AMHR2,ID2A,TGFBR2 |
Protein Function
E2F5 has several biochemical functions, for example, DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F5 itself. We selected most functions E2F5 had, and list some proteins which have the same functions with E2F5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LCP2,MARVELD3,STARD3,ARL14,POP1,SIRT2,BIRC5,KDRL,FLG,CLK1 |
| transcription factor activity, sequence-specific DNA binding | SPIB,HOMEZB,PPARAB,TEAD2,DMRT1,SALL4,AFF4,ZNF189,SLAMF7,HMGA1 |
| DNA binding | ZNF701,TLR8,CHD2,HOXA11B,SOX8,NEUROD6,RABGAP1,TCF3,ZBTB6,ING2 |
| sequence-specific DNA binding | SP1,ESRRGB,POU3F3B,SHOX,HEY2,PAX7A,NKX2-5,CREB3L3A,FOXA,NR2F5 |
| transcription factor binding | ARRB1,PARP1,APBB2,TFDP2,ZBTB49,PAX6,TRP53,MED1,MECP2,TAF7 |
Interacting Protein
E2F5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F5 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F5.
Tfdp2;Arid1a;Arid1b
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