E2F4
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Official Full Name
E2F transcription factor 4, p107/p130-binding -
Overview
The E2F family of transcrIPPtion factors regulates gene expression following heterodimerization with the DP family proteins, which promote transition to S phase from G1 phase. E2F activity is controlled by interactions with the retinoblastoma tumor suppre -
Synonyms
E2F4;E2F transcription factor 4, p107/p130-binding;transcription factor E2F4;E2F 4;p107/p130-binding protein;E2F-4
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
E2F4 involved in several pathways and played different roles in them. We selected most pathways E2F4 participated on our site, such as Adipogenesis,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | NCOA2,EGR2,CISD1,CNTFR,DVL1,AGPAT2,HMGA1-RS1,GTF3AA,GADD45A,AGT |
| Cell cycle | YWHABA,MAD2L2,NCAPG2,SDCCAG8,WEE2,GSK3B,DCTN2,SYCE1,CCNE1,MCM10 |
| Cell Cycle, Mitotic | SETA,SDCCAG8,MLF1IP,CENPK,HIST4H4,CDK11B,CENPE,KIF2C,GMNN,MIS12 |
| G1 Phase | CDKN2C,CDKN2B,CKS1B,CDKN2D,PIANP |
| Cyclin D associated events in G1 | CKS1B,CDKN2D,CDK7,PIANP,CDKN2C,CDKN2B |
| G0 and Early G1 | TOP2A,PIANP,LIN9,LIN52,MYBL2,DYRK1A,LIN37,LIN54 |
| E2F transcription factor network | RBBP8,SMARCA2,DHFR,CBX5,E2F6,CES5A,YY1,TRIM28,MYBL2,CES3 |
Protein Function
E2F4 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F4 itself. We selected most functions E2F4 had, and list some proteins which have the same functions with E2F4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOXK2,TFAM,ESRRA,HLTF,GCM1,GLIS2,LEF1,KLF4,ZIC3,STAT3 |
| protein domain specific binding | TNFAIP1,NLRP1,DDC,ST13,TJP1,XPO1,WHRN,KCNN2,CTBP1,YWHAZ |
| protein binding | SLC6A20,CSN3,IRAK4,STAMBPL1,DOCK10,RBM42,HTT,CDC42BPG,PCK2,IL17RA |
| transcription factor binding | STK36,ESR1,DNAJA3,SOX10,ENPP2,NBN,MYBBP1A,DIP2C,APBB2,NAB2 |
| DNA binding | DLX6A,POLA2,SMARCB1A,FOXE1,RABGEF1L,POLR2C,ZFP516,ZNF189,H3F3B.1,ZFP771 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CTCF,NKX3-2,JUNBA,CDX4,POU4F2,ETV1,OVOL1,MIXL1,TFAP4,FOXK2 |
| transcription factor activity, sequence-specific DNA binding | ZNF302,ZNF792,XBP1,NR2C2,TFE3,ZEB1,PPARDB,ZFP27,GATA6,EF1 |
Interacting Protein
E2F4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F4 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F4.
RBL2;TFDP2;LIN9;RB1;E7;MYBL2;RBL1;TFDP1
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References
- Demyanenko, SV; Uzdensky, AB; et al. PDT-induced epigenetic changes in the mouse cerebral cortex: A protein microarray study. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:262-270(2014).
- Yin, D; Xie, D; et al. DLK1: increased expression in gliomas and associated with oncogenic activities. ONCOGENE 25:1852-1861(2006).
