Ddn
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Official Full Name
dendrin -
Overview
Dendrin is a neural and renal protein whose exact function is still relatively unclear; however, its location in the brain and kidneys is well known as are some of the neural processes it affects. Within the brain, dendrin can be found in neurons and is most notably associated with sleep deprivation. Sleep deprivation causes some areas of the brain dendrin levels to increase, but this increase is insignificant and in total sleep deprivation causes a decrease of the mRNA and protein form of dendrin. Along with two other proteins, MAGI/S-SCAM and α-actinin, dendrin is linked to synaptic plasticity and memory formation in the brain. Nicotine levels have also been shown to have an effect on dendrin expression in the brain. Although unlike sleep deprivation, nicotine increases overall dendrin level. Originally thought to be a brain specific protein, there is now evidence to suggest that dendrin is also found in the kidneys. Dendrin is used to detect glomerulopathy or renal disease, based on its location in the kidneys. Within the kidneys it also works to prevent urinary protein loss. Most studies and information on dendrin pertain specifically to rat or mice brains. -
Synonyms
Gm748;DDN;dendrin
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DDN-3716H | Recombinant Human DDN protein, His-tagged | E.coli | Human | His | 484-711 aa | |
| DDN-1813R | Recombinant Rat DDN Protein | Mammalian Cell | Rat | His |
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| DDN-4390M | Recombinant Mouse DDN Protein | Mammalian Cell | Mouse | His |
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| DDN-1471R | Recombinant Rat DDN Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DDN-1471R-B | Recombinant Rat DDN Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DDN-2256M | Recombinant Mouse DDN Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DDN-2256M-B | Recombinant Mouse DDN Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
Ddn involved in several pathways and played different roles in them. We selected most pathways Ddn participated on our site, such as PodNet: protein-protein interactions in the podocyte,XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ddn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PodNet: protein-protein interactions in the podocyte | LIMS2,SDK1,FRAS1,CMIP,TENC1,FAM65A |
| XPodNet - protein-protein interactions in the podocyte expanded by STRING | ATP9A,SMARCD3,Siglece,PKD1,CARF,GMCL1,GJB6,GAB3,SNTB1,KCP |
Protein Function
Ddn has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ddn itself. We selected most functions Ddn had, and list some proteins which have the same functions with Ddn. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJL,FOSL2,CREB3,SFPI1,MSX1,FOSB,SNAI3,RBPJA,TFAP2A,HIST2H3A |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | RFX1A,FOSL1A,TFE3B,ETV6,HOXA5,HOXD13,KLF17,MTF1,KLF16,ZNF543 |
Interacting Protein
Ddn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ddn here. Most of them are supplied by our site. Hope this information will be useful for your research of Ddn.
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