Dact1
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Official Full Name
dishevelled-binding antagonist of beta-catenin 1 -
Overview
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] -
Synonyms
DACT1;dishevelled-binding antagonist of beta-catenin 1;DPR1;FRODO;HDPR1;DAPPER;THYEX3;DAPPER1;dapper homolog 1;dapper antagonist of catenin 1;heptacellular carcinoma novel gene 3;dapper, antagonist of beta-catenin, homolog 1;hepatocellular carcinoma novel gene 3 protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DACT1-12757Z | Recombinant Zebrafish DACT1 | Mammalian Cell | Zebrafish | His |
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| DACT1-2322H | Recombinant Human DACT1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DACT1-3483C | Recombinant Chicken DACT1 | Mammalian Cell | Chicken | His |
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| DACT1-7084HCL | Recombinant Human DACT1 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
Dact1 involved in several pathways and played different roles in them. We selected most pathways Dact1 participated on our site, such as Degradation of DVL,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dact1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TCF dependent signaling in response to WNT | RBBP5,ZNRF3,KLHL12,PYGO2,SOX32,RSPO1,WNT8-2,LGR5,RSPO4,SOX7 |
| Signal Transduction | BCO2L,CNGA1,TAC3,DLK1,FABP11B,TAAR1,GPR37B,RXFP2B,CDH5,GPR161 |
| Degradation of DVL | DVL2,DVL3,DVL1,HECW1,KLHL12,HECW1B |
| Signaling by Wnt | WIF1,USP34,CBY1,LGR4,RNF43,LGR5,ASH2L,SOX4B,FAM123B,C |
Protein Function
Dact1 has several biochemical functions, for example, beta-catenin binding,delta-catenin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Dact1 itself. We selected most functions Dact1 had, and list some proteins which have the same functions with Dact1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | PTBP3,SHROOM2,MED12,DACT2,TCF7L2,LZTS2A,KDM6B,SALL1,SLC9A3R1,AXIN1 |
| protein kinase C binding | PEA15A,PDLIM5,TIRAP,GLRX3,PLEK,HDAC7,FEZ1,HDAC7A,DACT3,MARCKS |
| protein binding | PLCE1,SLC30A3,PRX,RPS14,CCDC70,RAB11B,IFT43,NDUFS3,CDK5,ELP4 |
| protein kinase A binding | AKAP4,AKAP12B,AKAP14,DACT2,RPS3,AKAP12,Akap3,AKAP5,Akap2,DACT3 |
| delta-catenin binding | DACT2,DACT3,PLEKHA7A,PLEKHA7,CDH24,PTPRJ |
Interacting Protein
Dact1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dact1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Dact1.
DVL2;YWHAB;CTNNB1;GSK3B;AXIN1;Prkaca;YWHAQ;SFN
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References
- Gan, TQ; Tang, RX; et al. Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:714-721(2015).
- Schussel, JL; Kalinke, LP; et al. Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma. CANCER BIOMARKERS 15:11-17(2015).
