DYNC1H1
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Official Full Name
dynein, cytoplasmic 1, heavy chain 1 -
Overview
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. -
Synonyms
DYNC1H1;dynein, cytoplasmic 1, heavy chain 1;DNCH1, DNCL, DNECL, dynein, cytoplasmic, heavy polypeptide 1;cytoplasmic dynein 1 heavy chain 1;DHC1;Dnchc1;HL 3;p22;cytoplasmic dynein heavy chain 1;DHC1a;DKFZp686P2245;DNCH1;DNECL;DYHC;dynein heavy chain, cytosolic;dynein, cytoplasmic-like;HL-3;KIAA0325;dynein, cytoplasmic, heavy polypeptide 1;DNCL;CMT20
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- His
- GST
- Non
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DYNC1H1-1981R | Recombinant Rat DYNC1H1 Protein | Mammalian Cell | Rat | His |
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| DYNC1H1-2965H | Recombinant Human DYNC1H1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DYNC1H1-3835Z | Recombinant Zebrafish DYNC1H1 | Mammalian Cell | Zebrafish | His |
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| DYNC1H1-4905M | Recombinant Mouse DYNC1H1 Protein | Mammalian Cell | Mouse | His |
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| DYNC1H1-519HCL | Recombinant Human DYNC1H1 cell lysate | Human | Non |
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| DYNC1H1-1637H | Recombinant Human DYNC1H1 protein, His & T7-tagged | E.coli | Human | His&T7 | Ala20~Leu285 |
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| DYNC1H1-1975H | Recombinant Human DYNC1H1 Protein (Ala20-Leu285), N-His tagged | E.coli | Human | His | Ala20-Leu285 |
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| DYNC1H1-2579M | Recombinant Mouse DYNC1H1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DYNC1H1-2579M-B | Recombinant Mouse DYNC1H1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
DYNC1H1 involved in several pathways and played different roles in them. We selected most pathways DYNC1H1 participated on our site, such as Adaptive Immune System,Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYNC1H1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Centrosome maturation | CETN2,NINL,FGFR1OP,TUBB4B,CENPJ,CSNK1D,MAPRE1,MAPRE1A,DCTN3,TUBGCP3 |
| G2/M Transition | DYNC1I2,DCTN3,TUBGCP2,TUBG1,PLK4,CCP110,TSGA14,ACTR1A,DCTN1,CEP152 |
| Adaptive Immune System | KIF2A,AP2A1,CTSK,SIGLEC8,RNF138,CD160,AP2S1,HCST,MKRN1,RNF14 |
| Assembly of the primary cilium | BBS13,WDR35,NDE1,ARL13B,EXOC1,SETD6,PROL1,FLR,TTC30A1,IFT80 |
| Immune System | LILRB4,PCBP2,SIGLEC7,ASB9,MKRN1,CASPBL,ACTR2B,CD200R1,CFHL4,TRIM68 |
| Cell Cycle, Mitotic | KIF2B,CENPK,AHCTF1,NDEL1B,CKS1B,CEP57,TUBB4A,CSNK1D,CDKN2C,WAPAL |
| Cell cycle | DYNC1I2,VRK2,CDC23,CEP63,GADD45A,GADD45AB,CDKN2B,BARD1,SMC1B,CDKN1B |
| Anchoring of the basal body to the plasma membrane | TMEM216,CEP135,ODF2,BBS13,DCTN1A,RAB3IP,CEP72,MAPRE1B,CEP164,CEP57 |
Protein Function
DYNC1H1 has several biochemical functions, for example, ATP binding,ATPase activity,dynein light intermediate chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYNC1H1 itself. We selected most functions DYNC1H1 had, and list some proteins which have the same functions with DYNC1H1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity | VPS4A,SWSAP1,DNAH11,DNAH6,SMARCA4A,ABCG4B,ABCC12,MYO19,KIF21A,ABCG2D |
| poly(A) RNA binding | RPUSD3,SNRPG,PPIE,TFAM,DSP,SCAF4,C22orf28,GDI2,GLTSCR2,CCDC47 |
| dynein light intermediate chain binding | DYNC2H1 |
| protein binding | RAB1,ZMYM4,RUNX2,NDEL1,SPINK1,SET,PLEKHG4,AP5S1,VPS18,APOBEC3H |
| microtubule motor activity | KIF26A,KIF23,KIF2C,KIFC1,DNHD1,KIF4,KIF20B,KIF27,DYNC1I2,KLC1 |
| ATP binding | ULK1,ERBB4A,AK4,ABCB10,ACTR3,MYO18A,CDC42BPB,ATP1A1A.4,NARS2,MAPK12B |
Interacting Protein
DYNC1H1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYNC1H1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYNC1H1.
VCAM1;Cdk1;HTT;PSEN2;vpr;Ckap5;NFKB2;7242199;TOR1A
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References
- Huang, X; Wang, HL; et al. DYNLT3 Is Required for Chromosome Alignment During Mouse Oocyte Meiotic Maturation. REPRODUCTIVE SCIENCES 18:983-989(2011).
- Schneider, MA; Spoden, GA; et al. Identification of the dynein light chains required for human papillomavirus infection. CELLULAR MICROBIOLOGY 13:32-46(2011).
