DUSP9

  • Official Full Name

    dual specificity phosphatase 9

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

  • Synonyms

    DUSP9;dual specificity phosphatase 9;dual specificity protein phosphatase 9;map kinase phosphatase 4;MKP 4;MKP4;serine/threonine specific protein phosphatase;mitogen-activated protein kinase phosphatase 4;MKP-4

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
DUSP9-12220H Recombinant Human DUSP9, His-tagged E.coli Human His 1-381a.a.
DUSP9-1357R Recombinant Rhesus monkey DUSP9 Protein, His-tagged Mammalian Cell Rhesus macaque His
DUSP9-2948H Recombinant Human DUSP9 Protein, GST-tagged Wheat Germ Human GST
DUSP9-6769HCL Recombinant Human DUSP9 293 Cell Lysate HEK293 Human Non
DUSP9-1182R Recombinant Rhesus Macaque DUSP9 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DUSP9-1182R-B Recombinant Rhesus Macaque DUSP9 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DUSP9-2010H Recombinant Human DUSP9 Protein (Met1-Thr384), N-His tagged E.coli Human His Met1-Thr384
Dusp9-2692M Recombinant Mouse Dusp9 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DUSP9-4122HF Recombinant Full Length Human DUSP9 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 384 amino acids
DUSP9-5092H Recombinant Human DUSP9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    DUSP9 involved in several pathways and played different roles in them. We selected most pathways DUSP9 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology TRPC3,CACNG2,CSNK2A2,COL6A2,EFNA3,LIN28A,JAK1,NRP2,MEF2AA,TCF3B
    Cytokine Signaling in Immune system NRG2A,SPTBN2,LAMTOR2,TRIM45,DUSP7,EDAR,EGR1,TRIM62,SAMHD1,TRIM17
    Downstream signal transduction RASGEF1A,SPRED1,PHB,FRS2A,SPTBN2,PEA15A,RASGRP4,DUSP10,TRAT1,PAQR3B
    Downstream signaling of activated FGFR1 RASGRP4,SPRED1,PEA15A,RASGEF1A,PHB,PTPRA,AGO2,DUSP2,WDR83,IL17RD
    Axon guidance FGFR1B,NCK2,PAK1,DPYSL3,CLTB,ROBO2,EFNA1A,SCN2B,JAK1,EFNA5
    DAP12 signaling DUSP4,SPTA1,FGFR1B,SPRED2,KBTBD7,PTPRA,FGF10B,FGF18B,DUSP7,PEA15
    ARMS-mediated activation FGF8B,PSMD5,DLG4,FRS2B,MARK3,PTPRA,NEFLB,PAQR3B,PSMD10,JAK2
    DAP12 interactions NRG2A,RASGRP1,DUSP2,PAQR3B,RASGEF1A,FRS2,THEM4,PEBP1,KIR3DS1,AGO2

    Protein Function

    DUSP9 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,phosphoprotein phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP9 itself. We selected most functions DUSP9 had, and list some proteins which have the same functions with DUSP9. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine phosphatase activity KIAA1274,DUSP23A,PTPN11A,PTPN23A,DUSP7,CDC14AB,DUSP14,DUSP8A,DUSP5,DUSP3
    protein binding FNDC3B,OCIAD1,SH3RF1,C3orf39,PIKFYVE,POLD4,CCDC103,UGGT2,SDHB,PSMA3
    phosphoprotein phosphatase activity MTM1,PTPN11B,PPM1E,PTPN2B,CTDNEP1,PPM1LB,PTEN,PPM1DB,PPP1CBL,PPM1LA
    MAP kinase tyrosine/serine/threonine phosphatase activity PTPRQ,TENC1,DUSP18,NT5DC3,SACM1L,DUSP16,SGPP2,DUSP5,SACM1LA,DUSP6
    protein tyrosine/serine/threonine phosphatase activity PTPRQ,PXYLP1,DUSP23A,SSH1,DUSP23B,PTP4A3,DUSP14,EPM2A,CDC14A,SACM1LA

    Interacting Protein

    DUSP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP9.

    Mapk14;MAPK14;MAPK3;MAPK1;CDK4;GSK3B;Mapk1;Mapk3;STK4;MAPK11

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