DUSP8
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Official Full Name
dual specificity phosphatase 8 -
Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. -
Synonyms
DUSP8;dual specificity phosphatase 8;C11orf81, chromosome 11 open reading frame 81;dual specificity protein phosphatase 8;FLJ42958;H1 phosphatase;vaccinia virus homolog;HB5;HVH 5;serine/threonine specific protein phosphatase;H1 phosphatase, vac
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP8-2947H | Recombinant Human DUSP8 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
DUSP8 involved in several pathways and played different roles in them. We selected most pathways DUSP8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DUSP8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP8 itself. We selected most functions DUSP8 had, and list some proteins which have the same functions with DUSP8. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
DUSP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP8.
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References
- Liu, SL; Li, WQ; et al. Micro-RNA 21Targets Dual Specific Phosphatase 8 to Promote Collagen Synthesis in High Glucose-Treated Primary Cardiac Fibroblasts. CANADIAN JOURNAL OF CARDIOLOGY 30:1689-1699(2014).
- Lee, DH; Cho, S; et al. Dual-specificity Phosphatase 8 Promotes the Degradation of the Polyglutamine Protein Ataxin-1. BULLETIN OF THE KOREAN CHEMICAL SOCIETY 35:297-300(2014).
