DUSP7
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Official Full Name
dual specificity phosphatase 7 -
Overview
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK;(mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with;specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain;and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic;processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et;al., 2009 (PubMed 19228121)). -
Synonyms
DUSP7;dual specificity phosphatase 7;dual specificity protein phosphatase 7;MKP X;PYST2;dual-specificity phosphatase-7;dual specificity protein phosphatase PYST2;MKPX;DKFZp586F2224
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP7-2812H | Recombinant Human DUSP7 protein, His-tagged | E.coli | Human | His | 60-102 aa | |
| DUSP7-10163Z | Recombinant Zebrafish DUSP7 | Mammalian Cells | Zebrafish | His |
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| DUSP7-2946H | Recombinant Human DUSP7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DUSP7-516HCL | Recombinant Human DUSP7 cell lysate | Human | Non |
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| DUSP7-4120HF | Recombinant Full Length Human DUSP7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 320 amino acids |
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Involved Pathway
DUSP7 involved in several pathways and played different roles in them. We selected most pathways DUSP7 participated on our site, such as ARMS-mediated activation,Activated TLR4 signalling,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | KPNA3,SAMHD1,RASGRP1,PELI1,FRS2B,SPTA1,TNIP2,KLB,SPNA1,UBE2V1 |
| DAP12 signaling | TRAT1,THEM4,FGF20A,SPTBN1,PTPRA,LAMTOR2,CSF2RB,AGO1,RASGRP1,NEFLB |
| DAP12 interactions | KIR2DS2,AGO2,SPRED1,RASGRP1,SIGLEC15,SIRPB1,NEFLB,KLB,FRS2A,PHB |
| ARMS-mediated activation | CSF2RB,CRK,DUSP1,DLG4,DUSP10,CSF2RA,JAK2,SPNA1,SPRED2,FRS2 |
| Downstream signal transduction | FGF10B,JAK1,DAB2IPB,IL17RD,SPNA1,LAMTOR2,DUSP2,DUSP9,SPTA1,PEA15A |
| Activated TLR4 signalling | ALCAMB,APPA,S100A12,NOD1,PELI1,CREB1B,CHST13,APPB,MAPK14,CREB1 |
| Axon guidance | Plxna2,EFNA3,CSF2RB,EFNA1A,ARHGEF28,SEMA3D,PAK6,PSPN,HBEGF,PLXNA3 |
| Developmental Biology | KCNQ3,CTNNA2,EBF1,MED22,AP2M1,SCN3A,ACTR3,EGR2,CDON,ARPC3 |
Protein Function
DUSP7 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,protein binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP7 itself. We selected most functions DUSP7 had, and list some proteins which have the same functions with DUSP7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ALOX12B,HOMER2,NEK9,ATF2,FGF13,PRKAR2A,RNF24,GATA5,PIK3C2B,STK10 |
| MAP kinase tyrosine/serine/threonine phosphatase activity | DUSP1,DUSP10,TENC1,DUSP8A,DUSP4,CTDSPL2B,DUSP16,CTDSPL2A,SACM1L,DUSP14 |
| protein tyrosine phosphatase activity | MTMR7,EYA2,CDKN3,DUSP23A,PGP,DUSP8A,SSH2B,DUSP22A,EYA4,CDC25A |
Interacting Protein
DUSP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP7.
GHR;SPOP;MAPK1;MAPK14;ubiq_human;UBA1;UBE2D2
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References
- Carlos, AR; Escandell, JM; et al. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets. NATURE COMMUNICATIONS 4:-(2013).
- Klorin, G; Rozenblum, E; et al. Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines. CANCER GENETICS 206:191-205(2013).
