DUSP5
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Official Full Name
dual specificity phosphatase 5 -
Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. -
Synonyms
DUSP5;dual specificity phosphatase 5;dual specificity protein phosphatase 5;HVH3;VH1-like phosphatase 3;dual specificity protein phosphatase hVH3;serine/threonine specific protein phosphatase;DUSP
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP5-382H | Recombinant Human DUSP5 Protein, His-tagged | E.coli | Human | His | Met1~Glu135 | |
| Dusp5-383M | Recombinant Mouse Dusp5 Protein, His-tagged | E.coli | Mouse | His | Met1~Gln135 | |
| DUSP5-11845Z | Recombinant Zebrafish DUSP5 | Mammalian Cell | Zebrafish | His |
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| DUSP5-1977R | Recombinant Rat DUSP5 Protein | Mammalian Cell | Rat | His |
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| DUSP5-28378TH | Recombinant Human DUSP5 | Wheat Germ | Human | Non | 99 amino acids |
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| DUSP5-2943H | Recombinant Human DUSP5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DUSP5-330H | Recombinant Human DUSP5 Protein, His-tagged | E.coli | Human | His |
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| DUSP5-6772HCL | Recombinant Human DUSP5 293 Cell Lysate | HEK293 | Human | Non |
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| DUSP5-1636R | Recombinant Rat DUSP5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DUSP5-1636R-B | Recombinant Rat DUSP5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DUSP5-4110HF | Recombinant Full Length Human DUSP5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 384 amino acids |
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Involved Pathway
DUSP5 involved in several pathways and played different roles in them. We selected most pathways DUSP5 participated on our site, such as ARMS-mediated activation,ATF-2 transcription factor network,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ATF-2 transcription factor network | ATF2,RUVBL2,KCNA3,GADD45A,CBFB,HRK,JUND,DUSP10,DDIT3,JDP2 |
| Direct p53 effectors | GADD45A,FDXR,CEBPZ,CCNK,DUSP1,SMARCA4,CSE1L,S100A2,DDB2,FOXA1 |
| DAP12 signaling | DUSP4,SPNA1,IL17RD,GRAP2A,FRS3,PHB,PAQR3B,FRS2B,JAK1,PEA15A |
| Developmental Biology | TCF3A,PTPRA,MED26,FGF10B,ARPC2,INSM1B,COL4A4,TCF12,EFNA2A,CFC1 |
| Axon guidance | CSNK2B,SLIT1,NRG3,GFRA2,EFNA2,SEMA3AA,CFL2,CXCL12,ARHGEF28,NRP2 |
| ARMS-mediated activation | NEFLB,SPNA2,NTF7,PAQR3B,KLB,DUSP4,JAK3,CSF2,WDR83,NRG2A |
| Cytokine Signaling in Immune system | LAMTOR2,SPTB,DUSP10,UBE2V1,CRKL,TRIM14,TRIM6,GBP6,NUP50,IFIT11 |
| DAP12 interactions | NRG2A,PEA15A,CSF2RB,GRAP2B,ADRBK1,PAQR3A,HBEGF,MOV10,AGO1,NRG4 |
Protein Function
DUSP5 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,protein binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP5 itself. We selected most functions DUSP5 had, and list some proteins which have the same functions with DUSP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/serine/threonine phosphatase activity | DUSP13,DUPD1,SACM1L,PTP4A2B,SSH2,DUSP19A,CDC14C,CDKN3,RNGTT,DUSP11 |
| MAP kinase tyrosine/serine/threonine phosphatase activity | CTDSPL2A,CTDSPL2B,SGPP2,SACM1L,DUSP14,DUSP10,SACM1LB,PTPRQ,DUSP21,DUSP9 |
| protein tyrosine phosphatase activity | MTMR7,TPTE,PTP4A1,MTMR1A,CDC14C,PTPRK,EYA1,DUSP10,PTPRQ,DUSP26 |
| protein binding | HIST2H4,MYO18A,GDPD5,PPP2R5A,MCM2,FATE1,ITGA7,ARL2,APPL1,S100A14 |
Interacting Protein
DUSP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP5.
DUSP5
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References
- Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
- Moon, SJ; Lim, MA; et al. Dual-Specificity Phosphatase 5 Attenuates Autoimmune Arthritis in Mice via Reciprocal Regulation of the Th17/Treg Cell Balance and Inhibition of Osteoclastogenesis. ARTHRITIS & RHEUMATOLOGY 66:3083-3095(2014).
